Results 261 to 270 of about 825,337 (391)

Negative Impact of p21‐Activated Kinase 4‐Mediated AMP‐Activated Protein Kinase Inhibition on Sarcopenia in Mice and Humans

open access: yesMedComm, Volume 6, Issue 12, December 2025.
PAK4 is overexpressed in muscle atrophy and negatively correlates with muscle mass and function in humans. Inhibiting PAK4 activates AMPK/PGC‐1α‐driven mitochondrial biogenesis by blocking AMPKα2‐S491 phosphorylation while promoting muscle growth signals. PROTAC targeting PAK4 is a potential treatment for sarcopenia.
Jiacheng Du   +6 more
wiley   +1 more source

<b>MUSCLE β-ENOLASE UNDER TETRODOTOXIN-PARALYSIS OR CHRONIC STIMULATION OF THE SCIATIC NERVE </b>

open access: diamond, 1991
Toyohiko Satoh   +4 more
openalex   +2 more sources

Simultaneous zero echo time fMRI of rat brain and spinal cord

open access: yesMagnetic Resonance in Medicine, Volume 94, Issue 6, Page 2335-2346, December 2025.
Abstract Purpose Functional assessments of the central nervous system (CNS) are essential for many areas of research. fMRI typically targets either the brain or the spinal cord, but usually not both, because of the obstacles associated with simultaneous image acquisitions from distant fields of view (FOVs) with conventional MRI.
Hanne Laakso   +16 more
wiley   +1 more source

Laparoscopic Sciatic Nerve Dissection: A Reproducible Approach. [PDF]

open access: yesGynecol Minim Invasive Ther
Grigoriadis G   +3 more
europepmc   +1 more source

The Effect of Anti‐3‐Hydroxy‐3‐Methylglutaryl‐CoA Reductase (HMGCR) Human Autoantibodies on Muscle Regeneration in Mice

open access: yesMuscle &Nerve, Volume 72, Issue 6, Page 1300-1308, December 2025.
ABSTRACT Introduction/Aims Anti‐3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR) autoantibodies (aAbs) are pathogenic in immune‐mediated necrotizing myopathy (IMNM), partly through complement activation. C5 inhibition did not restore muscle strength in mice or patients with overt IMNM, suggesting additional pathogenic mechanisms.
Sarah Julien   +6 more
wiley   +1 more source

Analysis of Penetrating Injuries to the Sciatic Nerve, Highlighting Insights From Sudan. [PDF]

open access: yesPlast Reconstr Surg Glob Open
Kamal A   +4 more
europepmc   +1 more source

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