Results 121 to 130 of about 58,051 (308)

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

open access: yesIbrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Pemberian Citicoline Pada Tikus Cedera Saraf Mentalis: Ekspresi Gen SIRT1 Ganglion Trigeminal: the Administration of Citicoline on Rat Model with Mental Nerve Crush Injury: Gene Expression of Trigeminal Ganglion SIRT1 [PDF]

open access: yes, 2018
Cedera saraf perifer menyebabkan jumlah neuron menurun di ganglion sensorik, sehingga regenerasinya tidak baik. Pemberian Citicoline telah dilaporkan dapat memperbaiki kondisi fungsi motorik dan mencegah nyeri neuropati pada model tikus cedera saraf ...
Amri, I. (Imtihanah)   +3 more
core  

Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng   +6 more
wiley   +1 more source

Mas-related G-protein–coupled receptors inhibit pathological pain in mice [PDF]

open access: yes, 2010
An important objective of pain research is to identify novel drug targets for the treatment of pathological persistent pain states, such as inflammatory and neuropathic pain.
Altier   +49 more
core   +2 more sources

The Second Hit Hypothesis in Animal and Human Dystonia: The Role of Peripheral Nerve Trauma and Spinal Cord Injury

open access: yesMovement Disorders, EarlyView.
The “second‐hit” hypothesis proposes that both a genetic predisposition and an environmental insult—such as peripheral nerve trauma or spinal cord injury—are required for dystonia development. This review explores how neuroinflammation and maladaptive plasticity, triggered by nerve and spinal cord injury, contribute to dystonia pathogenesis.
Lisa Harder‐Rauschenberger   +1 more
wiley   +1 more source

Optoelectronic Interfaces for Nongenetic Modulation of Excitable Tissues

open access: yesSmall Methods, EarlyView.
This review summarizes recent advances in nongenetic optoelectronic technologies for the modulation of excitable biotissues, covering material selection, device design, and working principles, as well as characterization methods. Representative applications in in vitro and in vivo models of the cardiac, central, and peripheral nervous systems are ...
Qi Wang, Jinghua Li
wiley   +1 more source

Multiscale Engineering of Ion‐Conducting Gels for Sustainable Bioelectronic Systems

open access: yesSmall Methods, EarlyView.
This review highlights multiscale engineering strategies for ion‐conducting gels aimed at achieving sustainable bioelectronic systems. It systematically examines material‐level, device‐level, and system‐level approaches to ensure long‐term stability and functional integrity under physiological conditions, integrating molecular design, device ...
Ji Hong Kim   +6 more
wiley   +1 more source

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