Results 141 to 150 of about 56,654 (252)

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Peri‐operative pain management in major lower extremity amputation in vascular Surgery: a UK anaesthetic and vascular surgery Delphi consensus study*

Anaesthesia, Volume 81, Issue 5, Page 664-674, May 2026.
Summary Introduction Major lower extremity amputations occurring secondary to vascular disease remain prevalent worldwide. Pain surrounding these procedures is complex, multifactorial and associated with poor functional and psychosocial outcomes. The evidence base informing pain management approaches in major lower extremity amputations remain largely ...
Thanapon Ekkunagul, Caitlin Sara MacLeod, Anna Celnik, John Chalmers, Ross Thomson, Alan J. R. Macfarlane, David Bosanquet, John Nagy, Patrice Forget, the Delphi expert panel, Abhijoy Chakladar, Ahmed Abidia, Alan Fayaz, Alan Macfarlane, Alasdair Taylor, Alastair Thomson, Alexander Bell, Amy Sadler, Andrea Harvey, Andrew Mitchell, Andrew Tambyraja, Andrew William Garnham, Andrey Varvinskiy, Ankur Thapar, Anna Celnik, Caroline Curry, Catherine Western, Catriona Semple, Christopher G Davies, Craig Forrest, David Bosanquet, Denis Harkin, Diane Rosemary Hildebrand, Douglas James MacKenzie, Emma Elizabeth Florence Scott, Emma Jannine Baird, Ferdinand Serracino‐Inglott, Fiona Myint, Frances Kent, Francesco Torella, Gareth Harrison, George A. Antoniou, George Edward Smith, Graeme A McLeod, Ian Chetter, Indran Raju, John Chalmers, John Nagy, John O'Donoghue, Jonathan Paul Seeley, Kaji Sritharan, Keith Hussey, Keith Jones, Kersten Morgan Bates, Kevin Graham Mercer, Kieran Murphy, Lisa Anne Grimes, Matt Metcalfe, Maureen Sweeney, Michael McCusker, Michael Neil, Michelle Lamont, Mohamed Elsherif, Nat Haslam, Naveeta Maini, Nicholas Stuart Greaves, Patrick Coughlin, Patrice Forget, Peter Merjavy, Robert Hinchliffe, Rob Sayers, Ross Thomson, Russell William Jamieson, Sachin R Kulkarni, Sandeep Bahia, Sandip Nandhra, Serena Goon, Tanim Siddiqui, Tim Stansfield, Vanessa Fludder, Vikas Kaura, Vishal Gupta   +81 more
wiley   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, Volume 183, Issue 10, Page 2307-2323, May 2026.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2324-2340, May 2026.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Therapeutic potential of mesenchymal stem cells in peripheral nerve injuries in horses

Equine Veterinary Education, Volume 38, Issue 5, Page 252-260, May 2026.
Summary Peripheral nerve injuries (PNI) in horses represent a significant clinical challenge, frequently associated with functional deficits and reduced athletic performance. Conventional therapeutic approaches, primarily based on anti‐inflammatory treatments and rehabilitation, offer limited efficacy, driving the search for innovative alternatives. In
L. V. de Oliveira Ferreira, R. Martins Amorim   +1 more
wiley   +1 more source

Efficacy Comparison of Open Reduction and Robot‐Aided Infra‐Acetabular and Posterior Column Screws Fixation in Complex Acetabular Fractures Surgery: Union Plate Versus Reconstruction Plate

Orthopaedic Surgery, Volume 18, Issue 5, Page 999-1009, May 2026.
Robot‐aided technology allowed for precise and minimally invasive placement of periarticular long screws in open surgery for complex acetabular fractures, while using the Union Plate could decrease operation difficulty (fewer channel adjustments, less time for robotic manipulation and intraoperative plate contouring), operation time, and bleeding.
Jianan Chen, Yiran Feng, Runlin Zhu, Pengqing Zhang, Zhihua Zhao, Ziming Zhang, Xiaodong Guo, Lulu Tang, Kaifang Chen   +8 more
wiley   +1 more source

A VARIATION IN THE HIGH DIVISION OF THE SCIATIC NERVE AND ITS RELATION WITH PIRIFORMIS MUSCLE

National Journal of Medical Research, 2011
The aim of the study was to describe and analyze sciatic nerve variation especially the higher division within the lesser pelvis and its different routes of exit from pelvis.
Shailesh Patel, Mitesh Shah, Rakesh Vora, Ankur Zalawadia, S P Rathod   +4 more
doaj  

Intraperitoneal Alpha-Lipoic Acid to prevent neural damage after crush injury to the rat sciatic nerve

Journal of Brachial Plexus and Peripheral Nerve Injury, 2009
Objective Crush injury to the sciatic nerve causes oxidative stress. Alfa Lipoic acid (a-LA) is a neuroprotective metabolic antioxidant. This study was designed to investigate the antioxidant effects of pretreatment with a-LA on the crush injury of rat ...
Ozbag Davut, Nacitarhan Vedat, Senoglu Nimet, Kurutas Ergul, Atli Yalcin, Senoglu Mehmet, Altun Idris   +6 more
doaj  

Evaluating the Neuroprotective Effects of Levetiracetam on Experimental Sciatic Nerve Injury. [PDF]

J Clin Med
Demiriz Gulmez D, Hacioglu G, Cinar E, Keskin A, Cuvas Apan O, Apan A.   +5 more
europepmc   +1 more source

Evaluation of the Effects of the Anti-Inflammatory and Antioxidant Properties of Aloperine on Recovery in an Experimental Sciatic Nerve Injury Model. [PDF]

Antioxidants (Basel)
Ertanıdır M, Ertaş ES, Güleç A, Öztürk B, Ünlükal N, Çiftci S.   +5 more
europepmc   +1 more source