Results 121 to 130 of about 1,587,270 (262)

Canadian evidence‐based guidelines on spinal procedures for chronic pain

Anaesthesia, EarlyView.
Summary Introduction Interventional procedures are commonly used to diagnose and treat chronic pain of spinal origin but guidance on: their indications; frequency; technical conduct; requirements for image guidance; outcome measurement; and management of complications is lacking.
Anuj Bhatia, Philip Peng, Harsha Shanthanna, Yasmine Hoydonckx, James S. Khan, Elad Dana, Abeer Alomari, Tarvit Worravitudomsuk, Howard Meng, Martina Rekatsina, Ian Gilron, Andrea D. Furlan, Norman Buckley, Ian Beauprie, Roderick Finlayson, Paul Etheridge, Eldon Loh, Christopher Mares, Mohan Radhakrishna, Sebastian Mafeld, John X. Pereira, Hance Clarke, Shawn Marshall, Magali Robert, Pam Squire, Robert Tanguay, Danielle Alvares   +26 more
wiley   +1 more source

Melatonin and sciatic nerve injury repair: a current perspective

, 2018
Berrin Zuhal Altunkaynak,1 Burcu Delibaş,2 Gamze Altun,2 Ömür Gülsüm Deniz2 1Department of Histology and Embryology, Medical Faculty, Okan University, Istanbul; Turkey; 2Department of Histology and Embryology, Medical Faculty, Ondokuz
Altun G, Altunkaynak BZ, Deniz ÖG, Delibaş B   +3 more
core  

Sciatic nerve injury caused by pre-operative intraneural injection of local anaesthetic during total hip replacement.

, 2007
We report a case of iatrogenic sciatic nerve injury caused by pre-operative intraneural injection of local anaesthetic at total hip replacement. To our knowledge, this is unreported in the orthopaedic literature.
Crawfurd, EJ, Birch, R, Uppal, HS, Gwilym, Stephen   +3 more
core   +1 more source

Factors Affecting Surgical Outcomes Following Rotationplasty in Paediatric Sarcoma: A Literature Review

ANZ Journal of Surgery, EarlyView.
Rotationplasty is a durable limb‐salvage option for paediatric lower‐limb sarcoma. Across 58 studies and 1,217 patients, long‐term functional, psychosocial, and quality‐of‐life outcomes were favourable, often surpassing amputation and endoprosthetic reconstruction.
Rachel H. Ko, Stewart Morrison, Daniel J. Wilks   +2 more
wiley   +1 more source

The Exploratory Study of the PTEN-AKT/mTOR Signaling Pathway in the Corresponding Dorsal Root Ganglion during Compensatory Repair via Small Gap Amplification in Sciatic Nerve Injury

Journal of Integrative Neuroscience
Background: Peripheral nerve injury is a challenging orthopedic issue in clinical management that often leads to limb dysfunction or even disability in severe cases.
Fei Yu, Tiantian Qi, Yusong Yuan, Jian Weng, Tianbing Wang, Yuhui Kou, Hui Zeng   +6 more
doaj   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents

British Journal of Pharmacology, EarlyView.
Background and Purpose Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...
Patrik Meglić, Petra Šoštarić, Eirini Tsape, Melpomeni Galani, Ana Knezović, Laura Restani, Marco Pirazzini, Ornella Rossetto, Gareth B. Miles, Laskaro Zagoraiou, Ivica Matak   +10 more
wiley   +1 more source

High‐resolution spatial transcriptomic atlas of mouse soleus muscle: Unveiling single cell and subcellular heterogeneity in health and denervation

The FEBS Journal, EarlyView.
Seq‐Scope maps skeletal muscle transcriptomes at high spatial resolution while preserving histological context, revealing distinct responses of myofibers, neuromuscular junctions, and stromal cells to denervation. This spatial view uncovers fiber type‐specific and localized remodeling across intact muscle tissue.
Jer‐En Hsu, Lloyd Ruiz, Yongha Hwang, Steve D. Guzman, Chun‐Seok Cho, Weiqiu Cheng, Yichen Si, Peter Macpherson, Angelo Anacleto, Qingyang Zhao, Xiaoya Zhao, Mitchell Schrank, Goo Jun, Hyun Min Kang, Myungjin Kim, Susan V. Brooks, Jun Hee Lee   +16 more
wiley   +1 more source

Surgical management for sciatic nerve injury.

Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2003
To summarize surgical treatments and their corresponding curative effects on sciatic nerve injuries.Surgical treatments on sciatic nerve injury were performed in 28 patients from January 1990 to July 2000. The treatments included neurolysis, neurolysis plus partial nerve anastomosis, nerve anastomosis and nerve transplantation.
Chunlin, Hou, Shibo, Wang, Aimin, Chen, Wei, Zhang, Yong, Kuang, Yan, Liu, Chenghui, Yin, Shimin, Zhang, Jinwu, Wang   +8 more
openaire   +1 more source