Results 171 to 180 of about 58,051 (308)

Macrophage Targeting Protects Nerve Structure and Improves Muscle Innervation in a Mouse Model of Charcot‐Marie‐Tooth 2J

Glia, Volume 73, Issue 12, Page 2369-2385, December 2025.
Main Points Hemizygous POT124M mice develop a late‐onset axonopathy at 18 months of age. Pharmacological macrophage targeting with PLX5622 prevents distal axon degeneration in POT124M mutant mice and mitigates motor impairment. ABSTRACT In several previous studies, we have shown that macrophage targeting with the CSF‐1 receptor specific kinase (c‐FMS ...
Dennis Klein, Neslim Ercan, Xidi Yuan, Ghjuvan' Ghjacumu Shackleford, Anke Claessens, M. Laura Feltri, Lawrence Wrabetz, Maurizio D'Antonio, Rudolf Martini   +8 more
wiley   +1 more source

LncRNA SNHG16 promotes Schwann cell proliferation and migration to repair sciatic nerve injury [PDF]

, 2021
Yujie Chen, Zhiying Fan, Qirong Dong
openalex   +1 more source

Neuroprotective Effects of Halofuginone in Rat's Sciatic Nerve Injury

World Neurosurgery
The object of the present study was to investigate the neuroprotective effects of halofuginone-with its antifibrotic and anti-inflammatory effects-on peripheral nerve injuries frequently encountered in daily life, at the functional, pathological, and cellular levels through the use of electron microscopy.Forty Wistar rats were distributed into 4 groups.
Ömer Şahin, Tuncer Taşcıoğlu, Ayşegül Fırat, H. Selçuk Sürücü, Muzaffer Çaydere, Duran Berker Cemil   +5 more
openaire   +2 more sources

Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis

Glia, Volume 73, Issue 12, Page 2407-2426, December 2025.
Main Points DEOs are similar to satellite glial cells. DECs react to neuronal injury by promoting lipid metabolism, but do not proliferate. ECs reduce gap junctions upon neuronal injury. Perineural fibroblasts also contribute to the injury response. ABSTRACT During development and following injury‐induced neurogenesis, olfactory ensheathing cells (OECs)
Katja Senf, Sandor Nietzsche, Martin Westermann, Eva M. Neuhaus   +3 more
wiley   +1 more source

Role of Peptides in Skeletal Muscle Wasting: A Scoping Review

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Systemic muscle wasting is a prevalent condition that predicts adverse health outcomes in aging and disease. Despite its clinical relevance, the development of predictive biomarkers and effective pharmacological therapies remains limited. Peptides have recently gained attention for their diverse bioactive functions, positioning them
Petar Naumovski, Bart De Spiegeleer, Aster Wakjira, Christophe Van De Wiele, Vincent Mouly, Katarzyna Goljanek‐Whysall, Kauê Santana da Costa, Ewerton Cristhian Lima de Oliveira, Evelien Wynendaele, Anton De Spiegeleer   +9 more
wiley   +1 more source

Accelerated rehabilitation after proximal hamstring avulsion repair is safe and effective: Outcomes from randomized controlled trial of two different rehabilitation regimes

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 33, Issue 12, Page 4412-4425, December 2025.
Abstract Purpose The purpose of the study was to identify the safety and effectiveness of an accelerated (AR) versus conservative (CR) rehabilitation regimen following surgical repair of proximal hamstring tendon avulsions. Methods This prospective randomized controlled trial (RCT) allocated patients undergoing proximal hamstring tendon repair to ...
Randeep S. Aujla, Peter Edwards, Steven Cecchi, Shahbaz Malik, Brendan Ricciardo, Peter Annear, Jay Ebert, Peter D'Alessandro   +7 more
wiley   +1 more source

Intraperitoneal Alpha-Lipoic Acid to prevent neural damage after crush injury to the rat sciatic nerve

Journal of Brachial Plexus and Peripheral Nerve Injury, 2009
Objective Crush injury to the sciatic nerve causes oxidative stress. Alfa Lipoic acid (a-LA) is a neuroprotective metabolic antioxidant. This study was designed to investigate the antioxidant effects of pretreatment with a-LA on the crush injury of rat ...
Ozbag Davut, Nacitarhan Vedat, Senoglu Nimet, Kurutas Ergul, Atli Yalcin, Senoglu Mehmet, Altun Idris   +6 more
doaj  

Preliminary Establishment of a Method and System for Detecting Neural Tumor Boundaries Based on Optical Coherence Tomography

MedComm, Volume 6, Issue 12, December 2025.
This diagram illustrates the stepwise workflow involved in the development and application of the intraoperative swept‐source OCT system for brain tumor detection. The process begins with the creation of the OCT system, followed by data collection on light attenuation values from brain tumors and their boundaries.
Jiuhong Li, Jinwei Li, Gonggong Lu, Feilong Yang, Jing Li, Xin Qi, Rui Zhang, Xiang Li, Jiachen Sun, Haibo Rao, Xuhui Hui, Si Zhang   +11 more
wiley   +1 more source

Management and long-term outcome of pelvic fractures: a retrospective study of 43 cats [PDF]

, 2017
Bookbinder PE, Brown SG, Gentry SJ, Hudson EB, Hulse D, Muir P, Schrader SC, Shales C   +7 more
core   +2 more sources

Negative Impact of p21‐Activated Kinase 4‐Mediated AMP‐Activated Protein Kinase Inhibition on Sarcopenia in Mice and Humans

MedComm, Volume 6, Issue 12, December 2025.
PAK4 is overexpressed in muscle atrophy and negatively correlates with muscle mass and function in humans. Inhibiting PAK4 activates AMPK/PGC‐1α‐driven mitochondrial biogenesis by blocking AMPKα2‐S491 phosphorylation while promoting muscle growth signals. PROTAC targeting PAK4 is a potential treatment for sarcopenia.
Jiacheng Du, Hwang Chan Yu, Young Jae Moon, Sun‐Jung Yoon, Seung‐Yong Seo, Byung‐Hyun Park, Eun Ju Bae   +6 more
wiley   +1 more source