Results 71 to 80 of about 51,210 (327)

Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen

Advanced Science, EarlyView.
This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang, Mingyue Fan, Su Chin Heo, Sheila M. Adams, Thomas Li, Yuchen Liu, Qing Li, Claudia Loebel, Jason A. Burdick, X. Lucas Lu, David E. Birk, Farid Alisafaei, Robert L. Mauck, Lin Han   +13 more
wiley   +1 more source

Disc disease: A summary and review [PDF]

, 1993
A review of the etiology, clinical, radiological and laboratory presentation, differential diagnosis and management goals of disc disease is presented.
Walker, B.F.
core   +1 more source

Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis

Advanced Science, EarlyView.
Piezoelectric biomaterials convert mechanical forces into electrical signals, offering novel strategies to restore and modulate bone microenvironments for tissue engineering. This review examines molecular dipole origins, spatial arrangements, and pseudo‐piezoelectric mechanisms and highlights dipole‐engineering techniques for osteogenesis regulation ...
Xiyao Ni, Yufei Cui, Mojtaba Salehi, Mui Ling Sharon Nai, Kun Zhou, Cian Vyas, Boyang Huang, Paulo Bartolo   +7 more
wiley   +1 more source

Aligned Conductive Magnetic Nanofibers with Directional Magnetic Field Stimulation Promotes Peripheral Nerve Regeneration

Advanced Science, EarlyView.
Peripheral nerve injury necessitates alternatives to autografts. This study combines magnetic nanoparticles, oriented PCL fibers, and Ppy to create a conductive, magnetically active scaffold. In vitro and in vivo experiments demonstrated enhanced downstream pathways of calcium signaling, as revealed by transcriptome analysis.
Zheyuan Fan, Wei Yu, Xinggui Wen, Xiangdong Ding, Xiang Li   +4 more
wiley   +1 more source

Sciatica (lumbar radiculopathy) [PDF]

, 2017
Sciatica results from irritation or compression of the nerve root in the lumbosacral spine. Its symptoms include pain, numbness and tingling, which can extend down the back of the leg to the toes (National Institute for Health and Care Excellence (NICE),
Nuttall, Dilyse
core   +1 more source

3D‐Printing of Electroconductive MXene‐Based Micro‐Meshes in a Biomimetic Hyaluronic Acid‐Based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications

Advanced Science, EarlyView.
This study combined microscale 3D‐printing with 2D Ti3C2Tx MXene nanosheets to produce electroconductive microfibrous micro‐meshes. By embedding these MXene‐functionalized micro‐meshes within a growth‐supportive macroporous extracellular matrix (ECM)‐based biomaterial, multifunctional biomimetic MXene‐ECM scaffolds were developed.
Ian Woods, Dahnan Spurling, Sandra Sunil, Anne Marie O'Callaghan, Jack Maughan, Javier Gutierrez‐Gonzalez, Tara K. McGuire, Liam Leahy, Adrian Dervan, Valeria Nicolosi, Fergal J. O'Brien   +10 more
wiley   +1 more source

Predictive factors for treatment success of transforaminal epidural steroid injection in lumbar disc herniation-induced sciatica

Turkish Journal of Medical Sciences, 2019
Background/aim The aim of this study was to identify predictive factors for treatment success in transforaminal epidural steroid injection in patients with lumbar disc herniation-induced sciatica.
S. Şencan, A. Celenlioglu, R. Asadov, O. Gündüz   +3 more
semanticscholar   +1 more source

Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron‐Mediated Lung‐to‐Brain Axis

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSC) are considered a promising alternative for neuropathic pain (NP) treatment, but underlying mechanisms remain elusive. Huang et al. illustrate that a Npy2r sensory neuron‐related lung–brain axis contributes to MSC analgesia.
Jing Huang, Taihe Zhou, Yueming Sun, Yuanchen Ma, Yiwen Deng, Keyu Chen, Ruijie Li, Yuan Qiu, Tao Wang, Xiaoyong Chen, Li Huang, Lu Zhu, Xueyi Tu, Ying Wang, Zheming Liu, Rouchen Lin, Yunli Tong, Yuantao Li, Heshe Li, Lin Nie, Rui Fang, Jianqi Feng, Xuhong Wei, Xia Feng, Andy Peng Xiang, Xiaoran Zhang   +25 more
wiley   +1 more source

Cost-effectiveness of microendoscopic discectomy versus conventional open discectomy in the treatment of lumbar disc herniation [PDF]

, 2006
Background: Open discectomy is the standard surgical procedure in the treatment of patients with long-lasting sciatica caused by lumbar disc herniation.
Arts, M.P. (Mark), Brand, R. (René), Koes, B.W. (Bart), Peul, W.C. (Wilco), Thomeer, R.T.W.M. (Ralph)   +4 more
core   +2 more sources

Lumbar disc extrusions reduce faster than bulging discs due to an active role of macrophages in sciatica

Acta Neurochirurgica, 2019
Objective This retrospective observational histological study aims to associate the size and type of disc herniation with the degree of macrophage infiltration in disc material retrieved during disc surgery in patients with sciatica.
N. Djuric, Xiaoyu Yang, A. Barzouhi, Raymond W. J. G. Ostelo, S. G. V. Duinen, G. Nijeholt, B. F. W. Kallen, W. Peul, C. Vleggeert-Lankamp   +8 more
semanticscholar   +1 more source