Results 61 to 70 of about 30,872 (288)

Lumbar high-intensity zones on MRI: imaging biomarkers for severe, prolonged low back pain and sciatica in a population-based cohort.

The spine journal, 2020
BACKGROUND CONTEXT There is often discrepancy between clinical presentation and lumbar magnetic resonance imaging (MRI) findings. PURPOSE The purpose of this study was to assess the relationship of high-intensity zones (HIZs) on MRI with low back pain (
M. Teraguchi, J. Cheung, J. Karppinen, C. Bow, H. Hashizume, K. Luk, K. Cheung, D. Samartzis   +7 more
semanticscholar   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

A Millimeter‐Scale Implantable Magneto–Mechano–Electric Transducer Based on BTO Piezoelectric Ceramics for Remote Wireless Electrical Stimulation of Injured Sciatic Nerves

Advanced Science, EarlyView.
We report a fully wireless, circuit‐free neural stimulator built on a millimetric magneto‐mechano‐electric (MME) cantilever transducer (3 × 10 × 5 mm) with a barium titanate (BTO) piezoelectric ceramic core. Under low‐frequency alternating magnetic fields, the MME cantilever mechanically oscillates, inducing stress on the BTO element and thereby ...
Yijing Wang, Jingyu Tian, Zhe Xu, Cuiling Zhang, Jingen Wu, Ming Liu, Zhilu Ye, Xiaohui Zhang   +7 more
wiley   +1 more source

Elevated serum C-reactive protein levels in COVID-19 patients with sciatica: implications for prognosis and treatment strategies

Acta Clinica Croatica
To the best of our knowledge, no previous study has reported characteristics of C-reactive protein (CRP) levels in COVID-19 patients with comorbidities such as sciatica and lumbar syndrome. Th e objective of this study was to examine whether CRP levels
Aleksandar Kostić, Jovan Ilić, Nikola Stojanović, Radmilo Janković, Vesna Nikolov, Slavko Živković   +5 more
doaj   +1 more source

Stratified care versus usual care for management of patients presenting with sciatica in primary care (SCOPiC): a randomised controlled trial

The Lancet Rheumatology, 2020
Summary Background Sciatica has a substantial impact on individuals and society. Stratified care has been shown to lead to better outcomes among patients with non-specific low back pain, but it has not been tested for sciatica.
K. Konstantinou, Martyn Lewis, K. Dunn, R. Ogollah, M. Artus, Jonathan C Hill, Gemma Hughes, Michelle E Robinson, B. Saunders, B. Bartlam, J. Kigozi, S. Jowett, C. Mallen, E. Hay, D. A. van der Windt, N. Foster   +15 more
semanticscholar   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Inflammatory biomarkers do not distinguish between patients with sciatica and referred leg pain within a primary care population: results from a nested study within the ATLAS cohort

BMC Musculoskeletal Disorders, 2019
Background There is increasing interest in the role of pro-inflammatory cytokines in the pathogenesis of sciatica and whether these could be potential targets for treatment.
Samantha L. Hider, Kika Konstantinou, Elaine M. Hay, John Glossop, Derek L. Mattey   +4 more
doaj   +1 more source

Diagnosis and treatment of sciatica

British medical journal, 2019
Radiating leg pain, commonly referred to as ...
R. K. Jensen, A. Kongsted, P. Kjaer, B. Koes   +3 more
semanticscholar   +1 more source

Interaction between piperine and genes associated with sciatica and its mechanism based on molecular docking technology and network pharmacology

Molecular diversity, 2020
Piperine is the main active component of Piper longum L., which is also the main component of anti-sciatica Mongolian medicine Naru Sanwei pill. It has many pharmacological activities such as anti-inflammatory and immune regulation.
Jiu-wang Yu, H. Yuan, L. Bao, Lengge Si
semanticscholar   +1 more source

Longitudinal Single‐Axon‐Resolution Imaging of Peripheral Nerve Injury Response in Mice Using an Optical Window Implant

Advanced Science, EarlyView.
A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky, Emma Anisman, Ron Perez, Sophia Zhang, Morgan Hoffman, Daniel Hunter, Abigail Cherian, Jevon Bonner, Emilia Feria, Ahmed Ahmed, Muneeb Malik, Junwei Du, Leland C. Sudlow, David M. Brogan, Matthew D. Wood, Mikhail Y. Berezin   +15 more
wiley   +1 more source