Results 41 to 50 of about 24,138 (233)

NSAIDs in sciatica (NIS): study protocol for an investigator-initiated multicentre, randomized placebo-controlled trial of naproxen in patients with sciatica

Trials, 2022
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat sciatica, despite insufficient evidence from placebo-controlled trials.
Lars Grøvle, Eivind Hasvik, Rene Holst, Anne Julsrud Haugen   +3 more
doaj   +1 more source

Therapeutic ultrasound effects in a sciatica experimental model [PDF]

, 2009
A ciática possui grande prevalência geral e seu tratamento tende a resolver as causas de compressão nervosa. A fisioterapia objetiva reduzir os sintomas causados pela compressão.
BERTOLINI, Gladson Ricardo Flor, CARVALHO, Alberito Rodrigo de, CIENA, Adriano Policam, CUNHA, Núbia Broetto, MALLMANN, Juliana Schmatz, MOESCH, Juliana, MOURA, Paula Jaqueline de   +6 more
core   +2 more sources

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Recommendations for exercise adherence measures in musculoskeletal settings : a systematic review and consensus meeting (protocol) [PDF]

, 2014
Background: Exercise programmes are frequently advocated for the management of musculoskeletal disorders; however, adherence is an important pre-requisite for their success.
A Williams, AD Beswick, AD Woolf, C Martin, CB Terwee, CB Terwee, D Abrams, DC Turk, E Gucciardi, E Roddy, G Sarre, GS Kolt, GS Kolt, J Hardage, J Wens, JA Hayden, JA Ward, JD Childs, JL Jordan, JP Fuentes, JY Reginster, K Vella, K Weinger, KL Haywood, KLBJ Haywood, L Fernandes, LB Mokkink, M Fransen, M Gallagher, MA Holden, MK Murphy, MS Treuth, N Harvey, NA Beinart, NE Foster, NE Walsh, PR Williamson, R Forkan, RG Elbers, S McLean, S Parsons, SM McLean, The PRISMA group, TM Kay, World Health Organisation   +44 more
core   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Effect and neurophysiological mechanism of acupuncture in patients with chronic sciatica: protocol for a randomized, patient-assessor blind, sham-controlled clinical trial

Trials, 2019
Background Sciatica is a relatively frequent illness that easily becomes a chronic and relapsing condition. Although numerous systematic reviews have analyzed various therapies for sciatica, the validity of their included studies is limited.
Koh-Woon Kim, Kyungmo Park, Hi-Joon Park, Geon-Ho Jahng, Dae-Jean Jo, Jae-Heung Cho, Eun-Mo Song, Woo-Chul Shin, Ye-Ji Yoon, Soo-Jeon Kim, Seulgi Eun, Mi-Yeon Song   +11 more
doaj   +1 more source

A Rare Primary Pelvic Hydatid Cyst Presenting as Sciatica [PDF]

, 2012
Primary hydatid cyst in the pelvis is rare, and usually presents with pressure symptoms affecting the adjacent abdominal organs. We describe a rare hydatid cyst which was eroding the sacral hallow, protruding into the right sciatic foramen and presenting
Bafna, UD, Devi, UK, Rathod, PS, Reddihalli, PV   +3 more
core  

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Embracing Homoeopathy: A Paradigm Shift in Pain Management of Sciatica

Journal of Clinical and Biomedical Sciences
Increasing reports of sciatica irrespective of age and gender due to lifestyle, genetic or environmental factors. The unbearable pain of sciatica is a major problem interfering with a patient’s life.
Mohnyca Yumnam, Mrinal A Nerlekar
doaj   +1 more source

Evaluation of uptake and effect on patient-reported outcomes of a clinician and patient co-led chronic musculoskeletal pain self-management programme provided by the UK National Health Service [PDF]

, 2017
In the United Kingdom, chronic pain affects approximately 28 million adults, creating significant healthcare and socio-economic costs. The aim was to establish whether a programme designed to use best evidence of content and delivery will be used by ...
Anderson, Joanna K, Wallace, Louise M.
core   +1 more source