Results 71 to 80 of about 25,360 (296)
Advanced Science, EarlyView.Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie +12 more
wiley +1 more source
Protocol of the randomised placebo controlled pilot trial of the management of acute sciatica (SCIATICA): A feasibility study [PDF]
, 2018 Introduction Acute sciatica (symptom duration less than 4 weeks), a major cause of pain and disability, is a common presentation to medical practices and hospital emergency departments.
Smerdely, P ; https://orcid.org/ +4 more
core +1 more source
Advanced Science, EarlyView.Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai +16 more
wiley +1 more source
Frontiers in Pain ResearchBackgroundThere is an urgent need to confirm biomarkers reflecting the pathogenesis and targeted drugs of lower back pain or/and sciatica in clinical practice.
Yi-Ming Ren +9 more
doaj +1 more source
Differential Tissue‐Coupled Powering for Battery‐Free Injectable Electroceuticals
Advanced Science, EarlyView.A thread‐like injectable neural stimulator is powered through differential tissue‐coupled powering (DTCP), which harvests RF‐frequency tissue potentials with an elongated receiver while preserving a injectable cross‐section. The system integrates an ASIC, stimulation electrodes, and a portable transmitter, enabling wireless peripheral nerve stimulation,
Han Wu +13 more
wiley +1 more source
Sciatica due to pelvic hematoma: Case report [PDF]
, 2016 Sciatica is defined as pain in the sciatic nerve distribution. The most common reason of sciatica is radiculopathy due to lumbar disc hernia. Other causes can be congenital, acquired, infectious, neoplastic, or inflammatory.
Yilmaz, Muhammet Bahadir +2 more
core +1 more source
Frontiers in MedicineObjectiveThis study aimed to demonstrate and characterize a rare cervical spondylotic myelopathy (CSM) with sciatica-like pain as the main clinical manifestation through case presentation and systematic review.MethodsFour cases of CSM with sciatica-like ...
Changsheng Han +4 more
doaj +1 more source
Treatment of Sciatica Following Uterine Cancer with Acupuncture: A Case Report
Medicines, 2018 For women, gynaecological or obstetrical disorders are second to disc prolapse as the most common cause of sciatica. As not many effective conventional treatments can be found for sciatica following uterine cancer, patients may seek assistance from ...
Henry Xiao +3 more
doaj +1 more source