Results 71 to 80 of about 30,872 (288)

Low-level laser therapy, at 830 nm, for pain reduction in experimental model of rats with sciatica

Arquivos de Neuro-Psiquiatria, 2011
Chronic pain, resulting from nerve compression, is a common clinical presentation. One means of conservative treatment is low-level laser therapy, although controversial.
G R F Bertolini, E L Artifon, T S Silva, D M Cunha, P R Vigo   +4 more
doaj   +1 more source

Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial

JAMA Neurology, 2019
Importance Optimal pharmacologic treatment for chronic sciatica (CS) is currently unclear. While gabapentin (GBP) and pregabalin (PGB) are both used to treat CS, equipoise exists.
Kelvin Robertson, L. Marshman, David Plummer, Elena Downs   +3 more
semanticscholar   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study

Frontiers in Pain Research
BackgroundThere is an urgent need to confirm biomarkers reflecting the pathogenesis and targeted drugs of lower back pain or/and sciatica in clinical practice.
Yi-Ming Ren, Yi-Ming Ren, Wei-Yu Hou, Bao-You Fan, Yuan-Hui Duan, Yun-Bo Sun, Tao Yang, Han-Ji Zhang, Tian-Wei Sun, Meng-Qiang Tian   +9 more
doaj   +1 more source

Why managing sciatica is difficult: patients’ experiences of an NHS sciatica pathway. A qualitative, interpretative study

BMJ Open, 2020
Objectives Amid a political agenda for integrated, high-value care, the UK is implementing its Low Back and Radicular Pain Pathway. To align care with need, it is imperative to understand the patients’ perspective.
Clare Ryan, C. Pope, L. Roberts
semanticscholar   +1 more source

POLYURIA AND SCIATICA [PDF]

The Journal of Nervous and Mental Disease, 1892
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openaire   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Sciatica-like pain caused by cervical spondylotic myelopathy: four case reports and systematic review

Frontiers in Medicine
ObjectiveThis study aimed to demonstrate and characterize a rare cervical spondylotic myelopathy (CSM) with sciatica-like pain as the main clinical manifestation through case presentation and systematic review.MethodsFour cases of CSM with sciatica-like ...
Changsheng Han, Jingming Wang, Lei Wang, Qinglei Gong, Weimin Huang   +4 more
doaj   +1 more source

Case Report: Sciatic nerve schwannoma - a rare cause of sciatica [version 1; referees: 2 approved]

F1000Research, 2017
Herein we report a rare case of a sciatic nerve schwannoma causing sciatica in a 69-year-old female. Sciatic nerve schwannoma is a rare entity. It should always be considered as a possible cause of sciatica in patients that present with symptoms of ...
Sunil Munakomi, Pratyush Shrestha
doaj   +1 more source

Changes in resting‐state functional connectivity in nonacute sciatica with acupuncture modulation: A preliminary study

Brain and Behavior, 2020
To investigate the functional connectivity (FC) in nonacute sciatica and the neuronal correlation of acupuncture analgesia.
Ching-Hsiung Liu, T. Yeh, Y. Kung, Hung-Pin Tseng, Ching-Ju Yang, Tzu-Yi Hong, Chou-Ming Cheng, Jen-Lin Yang, Ta-Peng Wu, J. Hsieh, Fang-Pey Chen   +10 more
semanticscholar   +1 more source