Results 11 to 20 of about 194,910 (352)

Modernization of a Large Spinal Cord Injuries and Disorders Registry: The Veterans Administration Experience

Archives of Rehabilitation Research and Clinical Translation, 2022
Since the 1990s, Veterans Health Administration (VHA) has maintained a registry of Veterans with Spinal Cord Injuries and Disorders (SCI/Ds) to guide clinical care, policy, and research. Historically, methods for collecting and recording data for the VHA
Jennifer L. Sippel, PhD, Jennifer E. Daly, PhD, Linda Poggensee, MS, Kim D. Ristau, BS, Adam C. Eberhart, DPT, Katharine Tam, MD, Charlesnika T. Evans, PhD, Betsy Lancaster, BS, I. Manosha Wickremasinghe, MD, Stephen P. Burns, MD, Barry Goldstein, MD, PhD, Bridget M. Smith, PhD   +11 more
doaj   +1 more source

Impulse oscillometry identifies peripheral airway dysfunction in children with adenosine deaminase deficiency. [PDF]

, 2015
Adenosine deaminase-deficient severe combined immunodeficiency (ADA-SCID) is characterized by impaired T-, B- and NK-cell function. Affected children, in addition to early onset of infections, manifest non-immunologic symptoms including pulmonary ...
Candotti, Fabio, Hershfield, Michael S, Kohn, Donald B, Komarow, Hirsh D, Metcalfe, Dean D, Sokolic, Robert, Young, Michael   +6 more
core   +2 more sources

Eliminating SCID row: new approaches to SCID [PDF]

Hematology, 2014
AbstractTreatments for patients with SCID by hematopoietic stem cell transplantation (HSCT) have changed this otherwise lethal primary immune deficiency disorder into one with an increasingly good prognosis. SCID has been the paradigm disorder supporting many key advances in the field of HSCT, with first-in-human successes with matched sibling ...
openaire   +2 more sources

Development of a Multiplex Real-Time PCR Assay for the Newborn Screening of SCID, SMA, and XLA

International Journal of Neonatal Screening, 2019
Numerous studies have shown evidence supporting the benefits of universal newborn screening for primary immunodeficiencies (PID) and for Spinal Muscular Atrophy (SMA).
Cristina Gutierrez-Mateo, Anne Timonen, Katja Vaahtera, Markku Jaakkola, David M Hougaard, Jonas Bybjerg-Grauholm, Marie Baekvad-Hansen, Dea Adamsen, Galina Filippov, Stephanie Dallaire, David Goldfarb, Daniel Schoener, Rongcong Wu   +12 more
doaj   +1 more source

Fludarabine as a cost-effective adjuvant to enhance engraftment of human normal and malignant hematopoiesis in immunodeficient mice [PDF]

, 2018
There is still an unmet need for xenotransplantation models that efficiently recapitulate normal and malignant human hematopoiesis. Indeed, there are a number of strategies to generate humanized mice and specific protocols, including techniques to ...
A Rambaldi, A Terenzi, AM Carroll, AM Carroll, BS Andersson, CR Giver, D Niederwieser, DA Frank, DE Mosier, E McCormack, F Aversa, IF Khouri, K Tajima, L Luznik, L Weiss, M Furukawa, NC Kirkiles-Smith, S Goyama   +17 more
core   +1 more source

CLINICAL AND EPIDEMIOLOGICAL ASPECTS OF PRIMARY IMMUNODEFICIENCY DISEASES (PID) AND EARLY DIAGNOSIS OPTIONS

Медицинская иммунология, 2017
Neonatal screening for primary immunodeficiencies (PID) provides a unique opportunity for early detection of moderate to severe immune disorders. Thus, the patients could be provided with best available therapy, due to effective treatment according to ...
I. A. Korsunskiy, M. A. Gordukova, D. B. Munblit, I. G. Kozlov, A. P. Prodeus, A. A. Korsunskiy   +5 more
doaj   +1 more source

Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice. [PDF]

PLoS ONE, 2015
We have used homozygous albumin enhancer/promoter-driven urokinase-type plasminogen activator/severe combined immunodeficient (uPA/SCID) mice as hosts for chimeric mice with humanized livers.
Chise Tateno, Yosuke Kawase, Yoshimi Tobita, Satoko Hamamura, Hiroki Ohshita, Hiroshi Yokomichi, Harumi Sanada, Masakazu Kakuni, Akira Shiota, Yuha Kojima, Yuji Ishida, Hiroshi Shitara, Naoko A Wada, Hiromi Tateishi, Masayuki Sudoh, Shin-Ichiro Nagatsuka, Kou-Ichi Jishage, Michinori Kohara   +17 more
doaj   +1 more source

Diagnostic value of the Dutch version of the MCclean Screening instrument for BPD (MSI-BPD) [PDF]

, 2015
Borderline personality disorder (BPD) often goes unrecognized, and therefore a short but accurate screening tool is desired. The present study investigated the psychometric properties of the 10-item McLean Screening Instrument for BPD (MSI-BPD) in 159 ...
Andre, JA, Lobbestael, J, Verschuere, Bruno   +2 more
core   +2 more sources

Differentiation of Uterine Natural Killer Cells in Pregnant SCID (scid/scid) Mice

Journal of Veterinary Medical Science, 2011
To determine whether functional T- and B-cells can affect differentiation and/or proliferation of uterine natural killer (uNK) cells, their numbers in SCID mice (genotype, C.B.-17/Icr-scid/scid) were compared with those of control mice (genotype, C.B.-17/Icr-+/+) on days 8, 12 and 16 of pregnancy.
Masato, Hiyama, Ken Takeshi, Kusakabe, Ai, Kuwahara, Shoichi, Wakitani, Hamayun, Khan, Yasuo, Kiso   +5 more
openaire   +3 more sources

Elucidation of the Effects of a Current X-SCID Therapy on Intestinal Lymphoid Organogenesis Using an In Vivo Animal ModelSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Organ-level research using an animal model lacking Il2rg, the gene responsible for X-linked severe combined immunodeficiency (X-SCID), is clinically unavailable and would be a powerful tool to gain deeper insights into the symptoms
Tomonori Nochi, Shunichi Suzuki, Shun Ito, Shotaro Morita, Mutsumi Furukawa, Daiichiro Fuchimoto, Yoji Sasahara, Katsuki Usami, Kanae Niimi, Osamu Itano, Minoru Kitago, Sachiko Matsuda, Ayumi Matsuo, Yoshihisa Suyama, Yoshifumi Sakai, Guoyao Wu, Fuller W. Bazer, Kouichi Watanabe, Akira Onishi, Hisashi Aso   +19 more
doaj   +1 more source