Results 31 to 40 of about 187,417 (303)

Severe Combined Immunodeficiency Disorder due to a Novel Mutation in Recombination Activation Gene 2: About 2 Cases

Case Reports in Immunology, 2021
Severe combined immunodeficiency (SCID) comprises a heterogeneous group of inherited immunologic disorders with profound defects in cellular and humoral immunity. SCID is the most severe PID and constitutes a pediatric emergency.
Ibtihal Benhsaien, Fatima Ailal, Khadija Elazhary, Jalila El bakkouri, Abdallah Badou, Ahmed Aziz Bousfiha   +5 more
doaj   +1 more source

Adequate screening of youngsters for depressive characteristics [PDF]

, 2013
Introduction. In order to set up an effective early-detection of depressive symptoms in youngsters, the current study aims to investigate whether two measure moments of the Children's Depression Inventory (CDI) improve screening and whether a multi ...
Braet, Caroline, Roelofs, Jeffrey, Stark, Kevin, Theuwis, Lotte, Vandevivere, Eva   +4 more
core   +2 more sources

Newborn Screening for Severe Combined Immunodeficiency in Israel

International Journal of Neonatal Screening, 2017
Newborn screening (NBS) programs for severe combined immunodeficiency (SCID), the most severe type of primary immunodeficiency, are being implemented in more and more countries with every passing year.
Erez Rechavi, Atar Lev, Talia Saraf-Levy, Amos Etzioni, Shlomo Almashanu, Raz Somech   +5 more
doaj   +1 more source

Immunological Findings and Clinical Outcomes of Infants With Positive Newborn Screening for Severe Combined Immunodeficiency From a Tertiary Care Center in the U.S.

Frontiers in Immunology, 2021
The implementation of severe combined immunodeficiency (SCID) newborn screening has played a pivotal role in identifying these patients early in life as well as detecting various milder forms of T cell lymphopenia (TCL).
Vasudha Mantravadi, Jeffrey J. Bednarski, Michelle A. Ritter, Hongjie Gu, Ana L. Kolicheski, Caroline Horner, Megan A. Cooper, Maleewan Kitcharoensakkul, Maleewan Kitcharoensakkul   +8 more
doaj   +1 more source

Severe congenital T-lymphocytopenia may affect the outcome of neonatal intensive care

Biomedical Papers
Aim. Circular DNA segments TREC (T-cell receptor excision circles) formed during T-lymphocyte maturation in the thymus, are a sensitive marker of thymic lymphocyte production in a broader manner.
Ivana Hulinkova, Veronika Medova, Andrea Soltysova, Veronika Dobsinska, Andrej Ficek, Peter Ciznar   +5 more
doaj   +1 more source

RAG-1 Mutations Associated with B-Cell-Negative SCID Dissociate the Nicking and Transesterification Steps of V(D)J Recombination [PDF]

, 2001
Some patients with B-cell-negative severe combined immune deficiency (SCID) carry mutations in RAG-1 or RAG-2 that impair V(D)J recombination. Two recessive RAG-1 mutations responsible for B-cell-negative SCID, R621H and E719K, impair V(D)J recombination
Chang, Fu-Chung, Desiderio, Stephen, Li, Wenhui   +2 more
core   +2 more sources

Bilateral extensive CMV retinitis in a sick child – Harbinger of severe combined immunodeficiency

Journal of Pediatric Critical Care, 2017
Cytomegalovirus (CMV) retinitis is a marker of severe cellular immunodeficiency. Severe combined immunodeficiency (SCID) must be considered in infants presenting with CMV retinitis in a non-HIV setting.
H S Vinayaka, Tummala Sujith Kumar, G V Basavaraj, Sagar Bhattad   +3 more
doaj   +1 more source

FcγRII (CD32) modulates antibody clearance in NOD SCID mice leading to impaired antibody-mediated tumor cell deletion

Journal for ImmunoTherapy of Cancer, 2020
Background Immune compromised mice are increasingly used for the preclinical development of monoclonal antibodies (mAb). Most common are non-obese diabetic (NOD) severe combined immunodeficient (SCID) and their derivatives such as NOD SCID interleukin-2 ...
Robert J Oldham, C Ian Mockridge, Sonya James, Patrick J Duriez, H T Claude Chan, Kerry L Cox, Vicentiu A Pitic, Mark S Cragg   +7 more
doaj   +1 more source

A murine macrofilaricide pre-clinical screening model for onchocerciasis and lymphatic filariasis

Parasites & Vectors, 2014
Background New drugs effective against adult filariae (macrofilaricides) would accelerate the elimination of lymphatic filariasis and onchocerciasis. Anti-Onchocerca drug development is hampered by the lack of a facile model. We postulated that SCID mice
Alice Halliday, Ana F Guimaraes, Hayley E Tyrer, Haelly Mejane Metuge, Chounna Ndongmo Winston Patrick, Kengne-Ouafo Jonas Arnaud, Tayong Dizzle Bita Kwenti, George Forsbrook, Andrew Steven, Darren Cook, Peter Enyong, Samuel Wanji, Mark J Taylor, Joseph D Turner   +13 more
doaj   +1 more source

Retrospective TREC testing of newborns with Severe Combined Immunodeficiency and other primary immunodeficiency diseases

Molecular Genetics and Metabolism Reports, 2014
In Manitoba, Canada, the overall incidence of Severe Combined Immunodeficiency (SCID) is three-fold higher than the national average, with SCID overrepresented in two population groups: Mennonites and First Nations of Northern Cree ancestries.
O. Jilkina, J.R. Thompson, L. Kwan, P. Van Caeseele, C. Rockman-Greenberg, M.L. Schroeder   +5 more
doaj   +1 more source