Results 1 to 10 of about 789 (158)

Decreased TREC and KREC levels in newborns with trisomy 21 [PDF]

Frontiers in Pediatrics
Newborn screening (NBS) for severe combined immunodeficiency (SCID) has been widely implemented to enable early detection and intervention. Trisomy 21, commonly known as Down syndrome (DS), poses unique challenges in NBS due to its frequent association ...
Andrey Marakhonov, Anna Shcherbina, Dmitry Pershin   +2 more
exaly   +6 more sources

TREC/KREC Levels in Young COVID-19 Patients

Diagnostics, 2021
COVID-19 patients with acute respiratory distress syndrome (ARDS) have an immune imbalance when systemic inflammation and dysfunction of circulating T and B cells lead to a more severe disease.
, Artem Kuzovlev, Maryam Khadzhieva
exaly   +5 more sources

TREC and KREC Levels as a Predictors of Lymphocyte Subpopulations Measured by Flow Cytometry [PDF]

Frontiers in Physiology, 2019
Primary immunodeficiency diseases (PID) is a heterogeneous group of disorders caused by genetic defects of the immune system, which manifests clinically as recurrent infections, autoimmune diseases, or malignancies. Early detection of other PID remains a
Daniel Munblit, Maria Gordukova, Susanna Gordleeva   +2 more
exaly   +6 more sources

Expanding TREC and KREC Utility in Primary Immunodeficiency Diseases Diagnosis [PDF]

Frontiers in Immunology, 2020
Primary immunodeficiency diseases (PID) area heterogeneous group of disorders caused by genetic defects of the immune system, which manifest clinically as recurrent infections, autoimmune diseases or malignancies.
Alexey Zaikin, Daniel Munblit, Oleg Blyuss   +2 more
exaly   +7 more sources

Importance of TREC and KREC as molecular markers for immunological evaluation of down syndrome children [PDF]

Scientific Reports, 2023
Recurrent and severe infections occurred in children with Down Syndrome (DS) due to immunological parameter defects have been reported. The aim of the study is to evaluate the importance of using T-cell receptor excision circle (TREC) and kappa-deleting ...
Eman Eissa, Hanan H. Afifi, Assem M. Abo-Shanab, Manal M. Thomas, Mohamed B. Taher, Rania Kandil, Naglaa M. Kholoussi   +6 more
doaj   +4 more sources

TREC/KREC Levels and T and B Lymphocyte Subpopulations in COVID-19 Patients at Different Stages of the Disease

Viruses, 2022
Background: T and B cell-mediated immunity can be assessed using T cell receptor excision circle (TREC) and Kappa-deleting recombination excision circle (KREC) analysis, respectively, and successful implementation of this method requires evaluation of ...
Andrei Savchenko, Igor Kudriavtsev, Ilya Korsunskiy   +2 more
exaly   +3 more sources

Exploring TREC and KREC Levels in Nursing Home Residents and Staff and Their Association with SARS-CoV-2 Antibody Response After Vaccination [PDF]

Vaccines
Background: T-cell receptor excision circles (TRECs) and kappa-deleting recombination excision circles (KRECs) are markers of recent thymic and bone marrow output, respectively.
Eline Meyers, Natalja Van Biesen, Liselore De Rop, Tine De Burghgraeve, Marina Digregorio, Laëtitia Buret, Samuel Coenen, Beatrice Scholtes, Jan Y. Verbakel, Stefan Heytens, Piet Cools   +10 more
doaj   +2 more sources

Newborn screening for SCID and severe T- and B-cell lymphopenia in Ukraine: the first analysis of the results, 2022–2025 [PDF]

Frontiers in Immunology
IntroductionSevere combined immunodeficiency (SCID) and other profound T- and B-cell lymphopenias are life-threatening conditions that benefit from early diagnosis and treatment.
Oksana Boyarchuk, Halyna Makukh, Alla Volokha, Alla Volokha, Anastasiia Bondarenko, Anastasiia Bondarenko, Nataliia Mytsyk, Oksana Barvinska, Ivanna Shymanska, Yuliia Pohuliai, Mykola Veropotvelyan, Anastasia Haviley, Marharyta Hurina, Yaryna Romanyshyn, Maryna Trophymova, Iryna Hrabovska, Oksana Malko, Tetiana Tsanko, Oksana Tykholaz, Oleksandr Lysytsia, Nataliia Samonenko, Nataliia Olkhovych   +21 more
doaj   +2 more sources

TREC dynamics as a biomarker of naive T-cell homeostasis in traumatic brain injury: a longitudinal analysis [PDF]

Frontiers in Medicine
Post-traumatic immunosuppression complicates recovery from traumatic brain injury (TBI), increasing susceptibility to infection. Reliable biomarkers to assess immune status are required.
Darya A. Kashatnikova, Darya A. Kashatnikova, Alesya S. Gracheva, Alesya S. Gracheva, Ekaterina V. Kalinina, Vladislav E. Zakharchenko, Tatyana N. Krylova, Maryam B. Khadzhieva, Maryam B. Khadzhieva, Sergey S. Larin, Artem N. Kuzovlev, Lyubov E. Salnikova, Lyubov E. Salnikova   +12 more
doaj   +2 more sources

Primer estudio piloto para el tamizaje neonatal de linfopenias T y B en Colombia [PDF]

Biomédica: revista del Instituto Nacional de Salud
Introducción. La detección temprana de linfopenias congénitas facilitaría su tratamiento oportuno y la prevención de complicaciones serias, y optimizaría los recursos del sistema de salud. Objetivo. Realizar un estudio piloto para el tamizaje neonatal de
Sebastián Gutiérrez-Hincapié, Carlos Muskus-López, Isaura Pilar Sánchez, José Luis Franco-Restrepo, Claudia M. Trujillo-Vargas   +4 more
doaj   +2 more sources