Results 11 to 20 of about 3,562 (184)

Decreased TREC and KREC levels in newborns with trisomy 21 [PDF]

Frontiers in Pediatrics
Newborn screening (NBS) for severe combined immunodeficiency (SCID) has been widely implemented to enable early detection and intervention. Trisomy 21, commonly known as Down syndrome (DS), poses unique challenges in NBS due to its frequent association ...
Andrey Marakhonov, Anna Mukhina, Elena Vlasova, Irina Efimova, Natalya Balinova, Yulia Rodina, Dmitry Pershin, Zhanna Markova, Marina Minzhenkova, Nadezhda Shilova, Dzhaina Mudaeva, Djamila Saydaeva, Taisiya Irbaieva, Svetlana Matulevich, Elena Belyashova, Grigoriy Yakubovskiy, Inna Tebieva, Yulia Gabisova, Murat Ikaev, Nataliya Irinina, Liya Nurgalieva, Elena Saifullina, Tatiana Belyaeva, Olga Romanova, Sergey Voronin, Rena Zinchenko, Anna Shcherbina, Sergey Kutsev   +27 more
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Importance of TREC and KREC as molecular markers for immunological evaluation of down syndrome children [PDF]

Scientific Reports, 2023
Recurrent and severe infections occurred in children with Down Syndrome (DS) due to immunological parameter defects have been reported. The aim of the study is to evaluate the importance of using T-cell receptor excision circle (TREC) and kappa-deleting ...
Eman Eissa, Hanan H. Afifi, Assem M. Abo-Shanab, Manal M. Thomas, Mohamed B. Taher, Rania Kandil, Naglaa M. Kholoussi   +6 more
doaj   +4 more sources

TREC/KREC Levels in Young COVID-19 Patients

Diagnostics, 2021
COVID-19 patients with acute respiratory distress syndrome (ARDS) have an immune imbalance when systemic inflammation and dysfunction of circulating T and B cells lead to a more severe disease.
Maryam B. Khadzhieva, Ekaterina V. Kalinina, Sergey S. Larin, Daria A. Sviridova, Alesya S. Gracheva, Julia V. Chursinova, Vadim A. Stepanov, Ivan V. Redkin, Lyudmila S. Avdeikina, Alexander G. Rumyantsev, Artem N. Kuzovlev, Lyubov E. Salnikova   +11 more
doaj   +3 more sources

Expanding TREC and KREC Utility in Primary Immunodeficiency Diseases Diagnosis [PDF]

Frontiers in Immunology, 2020
Primary immunodeficiency diseases (PID) area heterogeneous group of disorders caused by genetic defects of the immune system, which manifest clinically as recurrent infections, autoimmune diseases or malignancies.
Ilya Korsunskiy, Ilya Korsunskiy, Oleg Blyuss, Oleg Blyuss, Oleg Blyuss, Maria Gordukova, Natalia Davydova, Alexey Zaikin, Natalia Zinovieva, Sergey Zimin, Robert Molchanov, Aminat Salpagarova, Alina Eremeeva, Maxim Filipenko, Andrey Prodeus, Anatoliy Korsunskiy, Anatoliy Korsunskiy, Peter Hsu, Peter Hsu, Peter Hsu, Daniel Munblit, Daniel Munblit, Daniel Munblit, Daniel Munblit   +23 more
doaj   +5 more sources

Newborn screening for SCID and severe T- and B-cell lymphopenia in Ukraine: the first analysis of the results, 2022–2025 [PDF]

Frontiers in Immunology
IntroductionSevere combined immunodeficiency (SCID) and other profound T- and B-cell lymphopenias are life-threatening conditions that benefit from early diagnosis and treatment.
Oksana Boyarchuk, Halyna Makukh, Alla Volokha, Alla Volokha, Anastasiia Bondarenko, Anastasiia Bondarenko, Nataliia Mytsyk, Oksana Barvinska, Ivanna Shymanska, Yuliia Pohuliai, Mykola Veropotvelyan, Anastasia Haviley, Marharyta Hurina, Yaryna Romanyshyn, Maryna Trophymova, Iryna Hrabovska, Oksana Malko, Tetiana Tsanko, Oksana Tykholaz, Oleksandr Lysytsia, Nataliia Samonenko, Nataliia Olkhovych   +21 more
doaj   +2 more sources

The TREC/KREC assay for the diagnosis and monitoring of patients with DiGeorge syndrome. [PDF]

PLoS ONE, 2014
DiGeorge syndrome (DGS) presents with a wide spectrum of thymic pathologies. Nationwide neonatal screening programs of lymphocyte production using T-cell recombination excision circles (TREC) have repeatedly identified patients with DGS.
Eva Froňková, Adam Klocperk, Michael Svatoň, Michaela Nováková, Michaela Kotrová, Jana Kayserová, Tomáš Kalina, Petra Keslová, Felix Votava, Hana Vinohradská, Tomáš Freiberger, Ester Mejstříková, Jan Trka, Anna Sedivá   +13 more
doaj   +4 more sources

Implementation of TREC/KREC detection protocol for newborn SCID screening in Bulgaria: a pilot study

Central European Journal of Immunology, 2023
Neonatal screening for inborn errors of immunity (IEI), based on quantification of T-cell-receptor- excision circles (TRECs) and kappa-deleting recombination-excision circles (KRECs) from dried blood spots (DBS), allows early diagnosis and improved ...
Marina Marinova, Atanaska Georgyeva, Viktoriya Yordanova, Nedelcho Ivanov, Valentina Atanasova, Elissaveta Naumova, Snezhina Mihailova Kandilarova   +6 more
doaj   +3 more sources

Primer estudio piloto para el tamizaje neonatal de linfopenias T y B en Colombia [PDF]

Biomédica: revista del Instituto Nacional de Salud
Introducción. La detección temprana de linfopenias congénitas facilitaría su tratamiento oportuno y la prevención de complicaciones serias, y optimizaría los recursos del sistema de salud. Objetivo. Realizar un estudio piloto para el tamizaje neonatal de
Sebastián Gutiérrez-Hincapié, Carlos Muskus-López, Isaura Pilar Sánchez, José Luis Franco-Restrepo, Claudia M. Trujillo-Vargas   +4 more
doaj   +2 more sources

Exploring TREC and KREC Levels in Nursing Home Residents and Staff and Their Association with SARS-CoV-2 Antibody Response After Vaccination [PDF]

Vaccines
Background: T-cell receptor excision circles (TRECs) and kappa-deleting recombination excision circles (KRECs) are markers of recent thymic and bone marrow output, respectively.
Eline Meyers, Natalja Van Biesen, Liselore De Rop, Tine De Burghgraeve, Marina Digregorio, Laëtitia Buret, Samuel Coenen, Beatrice Scholtes, Jan Y. Verbakel, Stefan Heytens, Piet Cools   +10 more
doaj   +2 more sources

TREC dynamics as a biomarker of naive T-cell homeostasis in traumatic brain injury: a longitudinal analysis [PDF]

Frontiers in Medicine
Post-traumatic immunosuppression complicates recovery from traumatic brain injury (TBI), increasing susceptibility to infection. Reliable biomarkers to assess immune status are required.
Darya A. Kashatnikova, Darya A. Kashatnikova, Alesya S. Gracheva, Alesya S. Gracheva, Ekaterina V. Kalinina, Vladislav E. Zakharchenko, Tatyana N. Krylova, Maryam B. Khadzhieva, Maryam B. Khadzhieva, Sergey S. Larin, Artem N. Kuzovlev, Lyubov E. Salnikova, Lyubov E. Salnikova   +12 more
doaj   +2 more sources