The TREC/KREC assay for the diagnosis and monitoring of patients with DiGeorge syndrome. [PDF]
PLoS ONE, 2014 DiGeorge syndrome (DGS) presents with a wide spectrum of thymic pathologies. Nationwide neonatal screening programs of lymphocyte production using T-cell recombination excision circles (TREC) have repeatedly identified patients with DGS.
Eva Froňková +13 more
doaj +4 more sources
Implementation of TREC/KREC detection protocol for newborn SCID screening in Bulgaria: a pilot study
Central European Journal of Immunology, 2023 Neonatal screening for inborn errors of immunity (IEI), based on quantification of T-cell-receptor- excision circles (TRECs) and kappa-deleting recombination-excision circles (KRECs) from dried blood spots (DBS), allows early diagnosis and improved ...
Marina Marinova +6 more
doaj +3 more sources
Photoinactivation vs repair of photosystem II as target of thermal stress in epipelic and epipsammic microphytobenthos communities. [PDF]
PLoS ONE, 2023 Microphytobenthos (MPB) inhabiting intertidal flats are exposed to large and sudden changes in temperature, often simultaneously with exposure to direct sunlight.
Cláudia Bártolo +2 more
doaj +2 more sources
Wafer-Scale 2D High-Entropy Transition Metal Dichalcogenide Thin-Film Catalysts for Efficient and Durable Photoelectrochemical Hydrogen Production. [PDF]
Adv MaterA wafer‐scale 2D high‐entropy (MoWTaNbRu)S2 thin‐film catalyst with a distorted 1T phase integrated onto p‐Si photocathode is designed for highly efficient and durable photoelectrochemical hydrogen evolution reaction. The high‐entropy effect in layered transition metal dichalcogenides optimizes hydrogen adsorption energetics, accelerates photogenerated
Jun SE +14 more
europepmc +2 more sources
Investigating the Variation of TREC/KREC in Combined Immunodeficiencies
Iranian Journal of Allergy, Asthma and Immunology, 2021 T-cell receptor excision circles (TREC)/Kappa-deleting recombination excision circles (KREC) assay has been recently recognized for detecting patients with primary (T- and/or B-cell) immunodeficiency (PID). We aimed to investigate the alterations of these biomarkers in some combined immunodeficiency patients compared to the healthy controls in ...
Leila Shakerian +11 more
openaire +3 more sources
Beyond TREC: Pivotal role of tandem TREC/KREC assay in Czech SCID NBS pilot programme [PDF]
Pediatric Allergy and ImmunologyAdam Klocperk, Jiří Litzman
exaly +2 more sources
Медицинская иммунология, 2022 Increasing attention is being paid to methods for detecting primary and secondary T and/or B cell immunodeficiencies. Their implementation into laboratory diagnostics would contribute to the early diagnostics of immunodeficiencies.
M. A. Saitgalina +4 more
doaj +1 more source
Frontiers in Immunology, 2020 The clinical experience gathered throughout the years has raised awareness of primary immunodeficiency diseases (PIDD). T cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) assays for thymic and bone marrow ...
Janette S. Y. Kwok +10 more
doaj +1 more source
A minimal physiologically-based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti-LAG-3 monoclonal antibody. [PDF]
CPT Pharmacometrics Syst PharmacolAbstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Michelet R +8 more
europepmc +2 more sources
Dilution Effect for High-Performance Multiple-Component Near-Infrared Organic Photodetectors. [PDF]
Adv Sci (Weinh)The dilution effect in multi‐component organic photodetector effectively suppresses non‐radiative decay and minimizes dark current, while energy‐level‐offset‐governed electron transfer between acceptors maintains efficient charge transport. This synergistic mechanism collectively enables remarkable device performance, including high detectivity and ...
Li Z +9 more
europepmc +2 more sources