Results 21 to 30 of about 3,562 (184)

TREC and KREC Levels as a Predictors of Lymphocyte Subpopulations Measured by Flow Cytometry [PDF]

Frontiers in Physiology, 2019
Primary immunodeficiency diseases (PID) is a heterogeneous group of disorders caused by genetic defects of the immune system, which manifests clinically as recurrent infections, autoimmune diseases, or malignancies. Early detection of other PID remains a
Ilya Korsunskiy, Ilya Korsunskiy, Ilya Korsunskiy, Oleg Blyuss, Maria Gordukova, Nataliia Davydova, Nataliia Davydova, Susanna Gordleeva, Robert Molchanov, Alan Asmanov, Dmitrii Peshko, Nataliia Zinovieva, Sergey Zimin, Vladimir Lazarev, Aminat Salpagarova, Maxim Filipenko, Ivan Kozlov, Andrey Prodeus, Andrey Prodeus, Andrey Prodeus, Anatoliy Korsunskiy, Anatoliy Korsunskiy, Peter Hsu, Peter Hsu, Daniel Munblit, Daniel Munblit, Daniel Munblit, Daniel Munblit   +27 more
doaj   +4 more sources

Photoinactivation vs repair of photosystem II as target of thermal stress in epipelic and epipsammic microphytobenthos communities. [PDF]

PLoS ONE, 2023
Microphytobenthos (MPB) inhabiting intertidal flats are exposed to large and sudden changes in temperature, often simultaneously with exposure to direct sunlight.
Cláudia Bártolo, Silja Frankenbach, João Serôdio   +2 more
doaj   +2 more sources

Determining Laboratory Reference Values of TREC and KREC in Different Age Groups of Iranian Healthy Individuals

Iranian Journal of Allergy, Asthma and Immunology, 2019
Assessment of the number of T-cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) copies has been recently described as biomarkers of newly formed T and B cells respectively.
Leila Shakerian, Zahra Pourpak, Somayeh Shamlou, Erna Domsgen, Anoshirvan Kazemnejad, Hossein Dalili, Maryam Nourizadeh   +6 more
doaj   +3 more sources

Dilution Effect for High-Performance Multiple-Component Near-Infrared Organic Photodetectors. [PDF]

Adv Sci (Weinh)
The dilution effect in multi‐component organic photodetector effectively suppresses non‐radiative decay and minimizes dark current, while energy‐level‐offset‐governed electron transfer between acceptors maintains efficient charge transport. This synergistic mechanism collectively enables remarkable device performance, including high detectivity and ...
Li Z, Wang X, Qiu X, Yang X, Bi L, Chen J, Wang Q, He Y, Xiong J, Yang R.   +9 more
europepmc   +2 more sources

Investigating the Variation of TREC/KREC in Combined Immunodeficiencies

Iranian Journal of Allergy, Asthma and Immunology, 2021
T-cell receptor excision circles (TREC)/Kappa-deleting recombination excision circles (KREC) assay has been recently recognized for detecting patients with primary (T- and/or B-cell) immunodeficiency (PID). We aimed to investigate the alterations of these biomarkers in some combined immunodeficiency patients compared to the healthy controls in ...
Leila Shakerian, Maryam Nourizadeh, Mohsen Badalzadeh, Mohammad Reza Fazlollahi, Raheleh Shokouhi Shoormasti, Shiva Saghafi, Behnaz Esmaeili, Zahra Alizadeh, Stephan Borte, Massoud Houshmand, Lennart Hammarström, Zahra Pourpak   +11 more
openaire   +3 more sources

Harmonizing TREC Thresholds in Newborn Screening for SCID: Insights From Russian Validation Cohort. [PDF]

J Clin Lab Anal
Refining TREC cutoff values in newborn screening (NBS) for SCID: ROC analysis of a large testing cohort supports increasing the TREC threshold from 100 to 150–200 copies/105 cells, improving assay sensitivity and enabling earlier detection of SCID and other immunodeficiencies.
Marakhonov A, Kalinina E, Larin S, Khadzhieva M, Dudina E, Mukhina A, Rodina Y, Efimova I, Balinova N, Sermyagina I, Shchagina O, Zinchenko R, Voronin S, Shcherbina A, Kutsev S.   +14 more
europepmc   +2 more sources

Determination of reference values for TREC and KREC in circulating blood of the persons over 18 years

Медицинская иммунология, 2022
Increasing attention is being paid to methods for detecting primary and secondary T and/or B cell immunodeficiencies. Their implementation into laboratory diagnostics would contribute to the early diagnostics of immunodeficiencies.
M. A. Saitgalina, N. E. Liubimova, Yu. V. Ostankova, R. N. Kuznetzova, A. A. Totolian   +4 more
doaj   +1 more source

A minimal physiologically-based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti-LAG-3 monoclonal antibody. [PDF]

CPT Pharmacometrics Syst Pharmacol
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Michelet R, Petersson K, Huisman MC, Menke-van der Houven van Oordt CW, Miedema IHC, Thiele A, Montaseri G, Pérez-Pitarch A, Busse D.   +8 more
europepmc   +2 more sources

Differentiating Creatine and Phosphocreatine In Vivo Using 3 T ¹H MR Spectroscopy. [PDF]

Magn Reson Med
ABSTRACT Purpose Validation and improvements to the proton MR spectroscopic measurement of creatine and phosphocreatine in vivo at 3 T. Methods Spectral simulations were used to evaluate and explore the mitigation of LCModel fitting bias due to lineshape, signal‐to‐noise (SNR) and non‐metabolite backgrounds with a focus on phosphocreatine and the ...
Hurd RE, Gu M, Adamson PM, Okamura K, Shibata M, Ono Y, Haidar M, Riemer K, Hanley FL, Spielman DM.   +9 more
europepmc   +2 more sources

TREC/KREC Levels and T and B Lymphocyte Subpopulations in COVID-19 Patients at Different Stages of the Disease

Viruses, 2022
Background: T and B cell-mediated immunity can be assessed using T cell receptor excision circle (TREC) and Kappa-deleting recombination excision circle (KREC) analysis, respectively, and successful implementation of this method requires evaluation of ...
Andrei A. Savchenko, Elena Tikhonova, Igor Kudryavtsev, Dmitry Kudlay, Ilya Korsunsky, Vasily Beleniuk, Alexandr Borisov   +6 more
doaj   +1 more source