Results 11 to 20 of about 102,493 (259)

Differentiation of Uterine Natural Killer Cells in Pregnant SCID (scid/scid) Mice

Journal of Veterinary Medical Science, 2011
To determine whether functional T- and B-cells can affect differentiation and/or proliferation of uterine natural killer (uNK) cells, their numbers in SCID mice (genotype, C.B.-17/Icr-scid/scid) were compared with those of control mice (genotype, C.B.-17/Icr-+/+) on days 8, 12 and 16 of pregnancy.
HIYAMA, Masato, KUSAKABE, Ken Takeshi, KUWAHARA, Ai, WAKITANI, Shoichi, KHAN, Hamayun, KISO, Yasuo   +5 more
openaire   +3 more sources

Modernization of a Large Spinal Cord Injuries and Disorders Registry: The Veterans Administration Experience

Archives of Rehabilitation Research and Clinical Translation, 2022
Since the 1990s, Veterans Health Administration (VHA) has maintained a registry of Veterans with Spinal Cord Injuries and Disorders (SCI/Ds) to guide clinical care, policy, and research. Historically, methods for collecting and recording data for the VHA
Jennifer L. Sippel, PhD, Jennifer E. Daly, PhD, Linda Poggensee, MS, Kim D. Ristau, BS, Adam C. Eberhart, DPT, Katharine Tam, MD, Charlesnika T. Evans, PhD, Betsy Lancaster, BS, I. Manosha Wickremasinghe, MD, Stephen P. Burns, MD, Barry Goldstein, MD, PhD, Bridget M. Smith, PhD   +11 more
doaj   +1 more source

An infant with disseminated bacillus Calmette-Guerin infection (BCGitis)

International Journal of Pediatrics & Adolescent Medicine, 2014
The bacillus Calmette Guerin (BCG) vaccine contains live attenuated Mycobacte-rium bovis bacteria. There is a long-standing controversy surrounding the efficacy of BCG against TB and whether it should be used.
Hamoud Al-Mousa
doaj   +1 more source

Congenital Athymia: Unmet Needs and Practical Guidance

Therapeutics and Clinical Risk Management, 2023
Evey Howley,1 E Graham Davies,1 Alexandra Y Kreins1,2 1Department of Immunology and Gene Therapy, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; 2Infection, Immunity and Inflammation Research & Teaching Department, University
Howley E, Davies EG, Kreins AY
doaj  

A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

Disease Models & Mechanisms, 2019
Mutations in the gene AK2 are responsible for reticular dysgenesis (RD), a rare and severe form of primary immunodeficiency in children. RD patients have a severely shortened life expectancy and without treatment die, generally from sepsis soon after ...
Alberto Rissone, Erin Jimenez, Kevin Bishop, Blake Carrington, Claire Slevin, Stephen M. Wincovitch, Raman Sood, Fabio Candotti, Shawn M. Burgess   +8 more
doaj   +1 more source

Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice. [PDF]

PLoS ONE, 2015
We have used homozygous albumin enhancer/promoter-driven urokinase-type plasminogen activator/severe combined immunodeficient (uPA/SCID) mice as hosts for chimeric mice with humanized livers.
Chise Tateno, Yosuke Kawase, Yoshimi Tobita, Satoko Hamamura, Hiroki Ohshita, Hiroshi Yokomichi, Harumi Sanada, Masakazu Kakuni, Akira Shiota, Yuha Kojima, Yuji Ishida, Hiroshi Shitara, Naoko A Wada, Hiromi Tateishi, Masayuki Sudoh, Shin-Ichiro Nagatsuka, Kou-Ichi Jishage, Michinori Kohara   +17 more
doaj   +1 more source

Immunological Emergency in Neonate: Case Report and Role of Early Screening

American Journal of Perinatology Reports, 2018
Healthy looking newborns may have severe combined immunodeficiency (SCID), and neonatologists frequently are the first physicians to encounter these patients.
Veronica Mugarab Samedi, Amy Shafey, Essa Al Awad, Luis Murguia Favela   +3 more
doaj   +1 more source

Elucidation of the Effects of a Current X-SCID Therapy on Intestinal Lymphoid Organogenesis Using an In Vivo Animal ModelSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Organ-level research using an animal model lacking Il2rg, the gene responsible for X-linked severe combined immunodeficiency (X-SCID), is clinically unavailable and would be a powerful tool to gain deeper insights into the symptoms
Tomonori Nochi, Shunichi Suzuki, Shun Ito, Shotaro Morita, Mutsumi Furukawa, Daiichiro Fuchimoto, Yoji Sasahara, Katsuki Usami, Kanae Niimi, Osamu Itano, Minoru Kitago, Sachiko Matsuda, Ayumi Matsuo, Yoshihisa Suyama, Yoshifumi Sakai, Guoyao Wu, Fuller W. Bazer, Kouichi Watanabe, Akira Onishi, Hisashi Aso   +19 more
doaj   +1 more source

Increased γ-H2A.X intensity in response to chronic medium-dose-rate γ-ray irradiation. [PDF]

PLoS ONE, 2012
BACKGROUND: The molecular mechanisms of DNA repair following chronic medium-dose-rate (MDR) γ-ray-induced damage remain largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: We used a cell function imager to quantitatively measure the fluorescence intensity ...
Takashi Sugihara, Hayato Murano, Kimio Tanaka   +2 more
doaj   +1 more source

Induced Pluripotent Stem Cell Meets Severe Combined Immunodeficiency [PDF]

Cell Journal, 2020
Severe combined immunodeficiency (SCID) is classified as a primary immunodeficiency, which is characterized by impaired T-lymphocytes differentiation. IL2RG, IL7Ralpha, JAK3, ADA, RAG1/RAG2, and DCLE1C (Artemis) are the most defective genes in SCID.
Reza Kouchaki, Bahareh Abd-Nikfarjam, Amirhosein Maali, Saeid Abroun, Farshad Foroughi, Sasan Ghaffari, Mehdi Azad   +6 more
doaj   +1 more source