Results 231 to 240 of about 196,305 (346)

Targeting the Notch1‐YY1‐ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8+ T‐Cell‐Driven Cancer Cell Pyroptosis

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In hepatocellular carcinoma (HCC), aberrantly activated Notch1 signaling induces its target gene YY1, which impairs immunotherapy efficacy by suppressing tumor cell‐ICAM1‐driven T cell activation and the mediated pyroptosis of T cells against tumor cells.
Ke Zhu, Fa‐Peng Zhang, Chao Qin, Zhi‐Xiao Song, Cai‐Ni Yang, Shu‐Sheng Lin, Xian‐Huan Yu, Wen‐Rui Wu, Chao‐Qun Liu, Chao Liu, Lei‐Bo Xu   +10 more
wiley   +1 more source

Circadian regulation of insulin secretion in transplanted human stem cell-derived pancreatic β-cells. [PDF]

Stem Cell Reports
Sen SK, Khashim Z, Belame SS, Hassoun S, Salomon T, Lewis-Brinkman S, Brown MR, Zhang L, Peterson QP, Matveyenko AV.   +9 more
europepmc   +1 more source

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

A novel <i>de novo IL2RG</i> nonsense mutation in a pediatric patient with X-linked severe combined immunodeficiency. [PDF]

Front Genet
Wang L, Ren A, He Y, Wang L, Wang S, Xie X, Tan M, Chen Y, Huang P, Du Z.   +9 more
europepmc   +1 more source

A Confirmatory Case of Severe Spondylocostal Dysostosis Caused by Biallelic Loss‐of‐Function of DMRT2

American Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 496-501, February 2026.
ABSTRACT Spondylocostal dysostosis (SCDO) is a rare genetic disorder characterized by abnormal development of the axial skeleton, resulting in malformations of the vertebrae and ribs that often impair lung development and lead to significant respiratory morbidity.
Jonathan Rips, Hagar Mor‐Shaked, Oded Shamriz, Raz Somech, Rawan Abu Omar, Smadar Eventov‐Friedman, Noa Ofek‐Shlomai, Dvorah Zaguer, Tamar Harel   +8 more
wiley   +1 more source

Abscopal-like antitumor effect induced by localized low-temperature plasma application of normal tissue in mice. [PDF]

J Radiat Res
Ono R, Sumitomo R, Wada K, Jinno R, Yanai H.   +4 more
europepmc   +1 more source

Functional and Nutraceutical Properties of Protein and Polyphenols Extracted From Agro‐Industrial Waste: A Comprehensive Review

eFood, Volume 7, Issue 1, February 2026.
The article underscores the promising future perspectives of utilizing agro‐industrial waste, envisioning sustainable production processes, and meeting the increasing demand for environmentally friendly and health‐promoting products. ABSTRACT The growing imperative for increased food production has propelled an example alteration in the perception of ...
Fakhar Islam, Ali Imran, Areesha Ahmed, Faiyaz Ahmed, Musarrat Rasheed, Amar Shankar, Neeraj Khare, Swati Sharma, Rutaba Nadeem, Abdela Befa Kinki   +9 more
wiley   +1 more source

HCB101: a novel potent ligand-trap Fc-fusion protein targeting the CD47-SIRPα pathway with high safety and preclinical efficacy for hematological and solid tumors. [PDF]

J Hematol Oncol
Wang JT, Tseng CL, Teng HF, Kuo PH, Cheng YC, Chen YJ, Lu YH, Wang CC, Shen TK, Wang HF, Tsai PL, Wu YC, Ho CH, Sun WT, Li YC, Lee YH, Hung YJ, Chen M, Li Z, Juo ZS, Zhai W, Liu SS.   +21 more
europepmc   +1 more source

Associations of Domain‐Specific Physical Activity With Mental Health Symptoms Among Finnish Employed Adults: A Population‐Based Study

European Journal of Sport Science, Volume 26, Issue 2, February 2026.
ABSTRACT Leisure‐time physical activity has consistently been associated with better mental health. However, evidence on active commuting and occupational physical activity is less conclusive. We examined cross‐sectional associations of domain‐specific physical activity with depressive symptoms and psychological distress among Finnish employed adults ...
Juuso J. Jussila, Anna Pulakka, Kaija Appelqvist‐Schmidlechner, Jaana I. Halonen, Jenni Ervasti, Paula Salo, Jouni Lahti, Santtu Mikkonen, Timo Lanki   +8 more
wiley   +1 more source

Double-hit RAG2 mutation presenting with hyper-immunoglobulin E and preserved T cells diagnostic challenge: a case report. [PDF]

J Med Case Rep
Hasan FM, Hamdan MH, Ismail AM, Malhis DL, Yadak DG, Warrad RK, Udwan SK, Sabbah YM.   +7 more
europepmc   +1 more source