Results 211 to 220 of about 102,493 (259)
Chest Radiographs for Distinguishing ADA-SCID from Other Forms of SCID [PDF]
Journal of Clinical Immunology, 2019 Early differentiation of adenosine deaminase deficient severe combined immunodeficiency (ADA-SCID) from other forms of SCID may initiate appropriate treatment interventions with the aim of metabolic detoxification and improved outcome. Our hypothesis was that previously described radiological features (inferior scapular angle squaring and spurring and ...
Alistair Calder +2 more
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Science Translational Medicine, 2011
Gene therapy for severe combined immunodeficiency: Do the benefits outweigh the risks?
Kit L, Shaw, Donald B, Kohn
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Gene therapy for severe combined immunodeficiency: Do the benefits outweigh the risks?
Kit L, Shaw, Donald B, Kohn
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Immunohistochemical and Ultrastructural Evidence for Myelopoiesis in the Scid/scid Mouse Thymus
The Histochemical Journal, 1999The ultrastructure of scid mouse thymus (a small encapsulated epithelial mass within the precardial fat pad) is described. The epithelium did not form cortex or medulla and hence remained relatively undifferentiated. Small unmyelinated nerves innervated the capsule, the major blood vessels and were distributed between the epithelial cells.
M D, Kendall, D P, Lane, U, Schumacher
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The American journal of pathology, 1995
T and B lymphocyte-deficient mice homozygous for the severe combined immunodeficiency (SCID) mutation can be immunologically engrafted with human lymphocytes. However, low levels of human peripheral blood mononuclear cell engraftment are commonly observed, impeding full use of this model. We now demonstrate that strain background in mice homozygous for
D L, Greiner +9 more
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T and B lymphocyte-deficient mice homozygous for the severe combined immunodeficiency (SCID) mutation can be immunologically engrafted with human lymphocytes. However, low levels of human peripheral blood mononuclear cell engraftment are commonly observed, impeding full use of this model. We now demonstrate that strain background in mice homozygous for
D L, Greiner +9 more
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1988
The scid mutation occurred in the C.B-17Icr (C.B-17) inbred strain, an immunoglobulin heavy chain (Igh) congenic partner strain of BALB/cAnlcr (BALB/c) . The C.B-17 strain was derived from the 13th backcross generation of the original C.B stock of M. Potter.
M, Bosma, W, Schuler, G, Bosma
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The scid mutation occurred in the C.B-17Icr (C.B-17) inbred strain, an immunoglobulin heavy chain (Igh) congenic partner strain of BALB/cAnlcr (BALB/c) . The C.B-17 strain was derived from the 13th backcross generation of the original C.B stock of M. Potter.
M, Bosma, W, Schuler, G, Bosma
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Defective repair of radiation-induced chromosomal damage in scid/scid mice
Cytogenetics and Cell Genetics, 2008The murine severe combined immunodeficiency (scid) mutation interferes with normal recombination of iramunoglobulin and T-cell receptor genes. This immunologic defect results in a lack of fully differentiated B and T cells in scid/scid mice. Animals homozygous for the scid mutation also display increased sensitivity to the damaging effects of ionizing ...
Disney, J E, Barth, A L, Shultz, L D
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Immune Deficiency in SCID Mice
International Reviews of Immunology, 1996Since the discovery of SCID mice in 1983, numerous studies utilizing these mice were carried out. These investigations can be classified into two major groups. First, the analysis of the immune defect has revealed defective V(D)J recombination and defective DNA double-strand break repair, and has lead to the identification of the candidate gene for ...
S, Nonoyama, H D, Ochs
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Spontaneous and experimental infections in scid and scid/beige mice.
Laboratory animal science, 1993Severe combined immunodeficient (scid) mice are valuable animals to study a variety of physiologic and disease processes. Their capacity to support multiple tissue xenografts permits these mice to be used as intermediate models for host-specific, fastidious organisms for which a small animal model has not been available previously.
D H, Percy, J R, Barta
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Scid Mice in Reproductive Biology
1989Immunodeficient mice of genotype scid/scid have been used to test two major theories relating immunology to reproduction. The first idea is that fetuses express antigens foreign to the mother and may be aborted by a process analogous to classical allograft rejection, particularly when there is subnormal maternal suppressor cell activity at the ...
D A, Clark +4 more
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