Results 231 to 240 of about 187,417 (303)

Gain‐of‐function enhancers optimize CAR‐NK cell‐based anti‐cancer immunotherapy

open access: yesImmunology &Cell Biology, Volume 104, Issue 5, Page 494-498, May‐June 2026.
Schematic overview of the two‐stage screening approach used to identify NK cell fitness genes. (A) CRISPRa mechanism, showing dCas9‐VP64‐mediated upregulation of target genes. (B) Whole‐genome CRISPRa screening in HER2‐CAR‐NK92 cells transduced with a CRISPR sgRNA library and transferred into mice bearing HT29 tumours, followed by tumour collection and
Emma Wong   +1 more
wiley   +1 more source

Why Is MS a More Frequent Complication of EBV Infection in Females?

open access: yesImmunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Multiple sclerosis (MS) is a T helper (Th) cell‐mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the etiology of MS was not well understood and the exact nature of the autoimmune reaction was speculative.
Shannon E. Dunn   +2 more
wiley   +1 more source

Rhenium-186-labeled <i>ortho</i>-hydroxythiobenzhydrazide: a potential theranostic agent for use in metastatic breast cancer. [PDF]

open access: yesRSC Adv
Mitra A   +13 more
europepmc   +1 more source

Psychostimulant treatment uniquely reduces left uncinate fasciculus microstructural integrity in ADHD youth with a familial risk for bipolar I disorder: a 12‐week DTI study

open access: yesJournal of Child Psychology and Psychiatry, Volume 67, Issue 5, Page 696-706, May 2026.
Background Bipolar I disorder (BD) is associated with reduced white matter microstructural integrity in the uncinate fasciculus (UF), a primary fiber tract connecting frontolimbic systems. Although familial history for BD, attention‐deficit/hyperactivity disorder (ADHD), and psychostimulants are important risk factors implicated in BD pathoetiology ...
Kun Qin   +10 more
wiley   +1 more source

Regional cerebellar structural deficits distinguish psychostimulant‐free ADHD youth with and without familial risk for bipolar I disorder: a cross‐sectional morphometric analysis

open access: yesJournal of Child Psychology and Psychiatry, Volume 67, Issue 5, Page 766-776, May 2026.
Background Although attention‐deficit/hyperactivity disorder (ADHD) with familial risk for bipolar I disorder (BD) may represent a more severe illness conferring greater risk for developing BD, associated neurostructural substrates remain poorly understood.
Biqiu Tang   +5 more
wiley   +1 more source

A single-cell digital PCR method tailored for quantification of HBV DNA positive cells in liver biopsy tissues. [PDF]

open access: yesJ Transl Med
Li J   +9 more
europepmc   +1 more source

Paternal sleep deprivation and cardiac dysfunction in offspring: A perspective of myocardial hypertrophy

open access: yesExperimental Physiology, Volume 111, Issue 5, Page 2518-2527, 1 May 2026.
Abstract The objective of this work is to assess the effects and potential process of paternal acute sleep deprivation on cardiac function in their offspring. Male and female C57BL/6N mice aged 8–9 weeks (n = 4–5 mice/group) were used. Male mice were selected to construct an acute sleep deprivation model using the modified multiple platform method ...
Yingying Zhang   +12 more
wiley   +1 more source

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