Severe combined immunodeficiency with BCG-osis by salvage therapy with allogeneic hematopoietic stem cell transplantation: cases report and literature review. [PDF]
Jiao Y +9 more
europepmc +1 more source
Gain‐of‐function enhancers optimize CAR‐NK cell‐based anti‐cancer immunotherapy
Schematic overview of the two‐stage screening approach used to identify NK cell fitness genes. (A) CRISPRa mechanism, showing dCas9‐VP64‐mediated upregulation of target genes. (B) Whole‐genome CRISPRa screening in HER2‐CAR‐NK92 cells transduced with a CRISPR sgRNA library and transferred into mice bearing HT29 tumours, followed by tumour collection and
Emma Wong +1 more
wiley +1 more source
BCGitis and BCGosis: Clinical Spectrum, Immunological Mechanisms, and Risk Management. [PDF]
Liu Q, Dai X, Wei S.
europepmc +1 more source
Why Is MS a More Frequent Complication of EBV Infection in Females?
ABSTRACT Multiple sclerosis (MS) is a T helper (Th) cell‐mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the etiology of MS was not well understood and the exact nature of the autoimmune reaction was speculative.
Shannon E. Dunn +2 more
wiley +1 more source
Rhenium-186-labeled <i>ortho</i>-hydroxythiobenzhydrazide: a potential theranostic agent for use in metastatic breast cancer. [PDF]
Mitra A +13 more
europepmc +1 more source
Background Bipolar I disorder (BD) is associated with reduced white matter microstructural integrity in the uncinate fasciculus (UF), a primary fiber tract connecting frontolimbic systems. Although familial history for BD, attention‐deficit/hyperactivity disorder (ADHD), and psychostimulants are important risk factors implicated in BD pathoetiology ...
Kun Qin +10 more
wiley +1 more source
Global research landscape of inborn errors of immunity: a bibliometric analysis (1991-2025). [PDF]
Wu Q, Gao J, Yuan Y, Yang H, Fu Q.
europepmc +1 more source
Background Although attention‐deficit/hyperactivity disorder (ADHD) with familial risk for bipolar I disorder (BD) may represent a more severe illness conferring greater risk for developing BD, associated neurostructural substrates remain poorly understood.
Biqiu Tang +5 more
wiley +1 more source
A single-cell digital PCR method tailored for quantification of HBV DNA positive cells in liver biopsy tissues. [PDF]
Li J +9 more
europepmc +1 more source
Abstract The objective of this work is to assess the effects and potential process of paternal acute sleep deprivation on cardiac function in their offspring. Male and female C57BL/6N mice aged 8–9 weeks (n = 4–5 mice/group) were used. Male mice were selected to construct an acute sleep deprivation model using the modified multiple platform method ...
Yingying Zhang +12 more
wiley +1 more source

