Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu +4 more
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Posttransplant B cell Development and Function in Patients with B cell Positive SCID Caused by Pathogenic Variants in IL2RG and JAK3. [PDF]
Jacobsen EM +13 more
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Physapubescin B may interfere with multiple cancer‐associated signaling pathways by inhibiting Ras/Raf/mitogen‐activated protein kinase kinase/extracellular signal‐regulated kinase (Ras/Raf/MEK/ERK) signaling and vascular endothelial growth factor (VEGF)‐dependent angiogenesis.
Wojciech Koch +11 more
wiley +1 more source
Transgenic expression of human signal regulatory protein alpha (SIRPα) in BALB/c Rag2<sup>null</sup>/Jak3<sup>null</sup> immunodeficient mice enhances human lymphoma xenografts by reducing phagocytosis. [PDF]
Panaampon J, Ogawa T, Shiota A, Okada S.
europepmc +1 more source
ABSTRACT Background Although a key factor in understanding intergenerational transmission, family history of chronic pain deserves greater attention, particularly about its role as a potential mediating factor on current psychophysical status, together with other underestimated parameters (e.g., psychiatric comorbidity).
Simona Pupo +5 more
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Outcome of second conditioned allogeneic stem cell transplant in children with non-SCID inborn errors of immunity. [PDF]
Nademi Z +36 more
europepmc +1 more source
ABSTRACT Background Quality of life (QoL) in head and neck cancer (HNC) is influenced by complex biopsychosocial factors, yet few longitudinal studies have examined these relationships immediately post‐treatment. Methods In this prospective study, 232 patients newly diagnosed with primary HNC completed psychometric assessments, clinical interviews, and
Haley Deamond +18 more
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Construction and characterization of novel <i>Mycobacterium tuberculosis</i>-derived triple and quadruple knockout vaccines against tuberculosis. [PDF]
Garnica O +13 more
europepmc +1 more source
Sphingosine‐1‐Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis
In high‐grade serous ovarian cancer, malignant ascites frequently arise as ovarian cancer cells shed from the primary tumor and aggregate into tumorspheres, severely limiting treatment success. To date, little is known about the mechanisms governing tumorsphere endurance and metastasis within the ascites once formed.
Núria Gendrau‐Sanclemente +12 more
wiley +1 more source
Case Report: Infant with vaccine-associated paralytic poliomyelitis unveils global disparities in care for inborn errors of immunity. [PDF]
Chan CM +14 more
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