Results 181 to 190 of about 102,493 (259)

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, Volume 13, Issue 44, 7 August 2026.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Repurposing Hetrombopag for Multiple Myeloma by Targeting PNPO: A Celastrol-Inspired Approach. [PDF]

Basic Clin Pharmacol Toxicol
Yu T, Wang C, Xie J, Wei Y, Cui H, Zhang H, Zhou F, Deng Z, Yang Y, Gu C.   +9 more
europepmc   +1 more source

Harnessing Repurposed Drugs to Enhance Temozolomide Efficacy in Glioblastoma

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Glioblastoma (GB) is the most aggressive primary malignant brain tumor in adults and remains associated with poor survival despite surgical resection followed by radiotherapy and temozolomide (TMZ) chemotherapy. Intrinsic and acquired resistance to TMZ, including MGMT‐dependent DNA repair and activation of pro‐survival pathways ...
Ali Nakhaei, Atefeh Taghavi, Amir R. Afshari, Farzaneh Davoudi, Elaheh Gheybi, Mohammad Jalili‐Nik   +5 more
wiley   +1 more source

Tracing the in vivo behavior of nucleated cultured red blood cells generated from hematopoietic stem and progenitor cells. [PDF]

Stem Cell Res Ther
Xu L, Yang Z, Liang L, Zhang J, Yuan X, Liu P, Dong Q, Pei X, Qu M, Yue W, Xie X.   +10 more
europepmc   +1 more source

Clinical Validation of a QSP Model for ISB 2001, a Trispecific T Cell Engager to Support Optimal FIH Study Design in RRMM Patients

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 452-464, August 2026.
ISB 2001 is a trispecific antibody that binds to two tumor‐associated antigens (TAA), CD38 and BCMA, and crosslinks to CD3 on T cells resulting in T cell‐mediated cytotoxicity of tumor cells expressing these TAAs. ISB 2001 is currently being tested in relapsed and/or refractory multiple myeloma (RRMM) patients in the first‐in‐human (FIH) TRIgnite‐1 ...
Vinu Chandralayam Ayyappa Menon, Tomomi Matsuura, Beata Holkova, Girish S. Gudi, Adam Drake, Maria Pihlgren, Piet H. van der Graaf, Sunitha GN, Andrew Garton, Mario Perro, Cyril Konto, Lida Pacaud   +11 more
wiley   +1 more source

Perinatal depression and breastfeeding: a longitudinal investigation of the bidirectional relationship in Pakistan. [PDF]

Arch Womens Ment Health
Haight SC, Bates LM, Chung EO, Collins A, Frost A, Kachoria AG, Shartle K, Sikander S, Maselko J.   +8 more
europepmc   +1 more source

Psychiatric Morbidity Is Overrepresented in Young Girls at High Risk of Developing Anorexia Nervosa

International Journal of Eating Disorders, Volume 59, Issue 8, Page 1740-1752, August 2026.
ABSTRACT Objective Psychiatric comorbidity frequently presents in anorexia nervosa (AN). Yet, the premorbid mental health status is relatively unknown. The aim of this study was to map out psychiatric morbidity and psychopathology among girls at familial high risk (FHR) of developing AN, thereby detecting possible underlying vulnerabilities preceding ...
Karin Dahlin, Kajsa Järvholm, Jovanna Dahlgren, Elisabet Wentz   +3 more
wiley   +1 more source

Outcomes following matched sibling donor transplantation for severe combined immunodeficiency: a report from the PIDTC. [PDF]

Blood Adv
Rayes A, Logan BR, Liu X, Dara J, Buckley RH, Oved JH, Kapoor N, Kapadia M, Chandra S, Martinez CA, Bunin NJ, Chandrakasan S, Chen K, Bednarski JJ, Haines HL, Eissa H, Talano JM, Keller MD, Ebens CL, Chaudhury S, Shereck EB, Aquino VM, Knutsen AP, Alexander JL, Gillio AP, Chellapandian D, Shah AJ, Miller HK, Vander Lugt MT, Seroogy CM, Dorsey MJ, Mousallem T, Parrott RE, O'Reilly RJ, Aguayo-Hiraldo PI, Prockop SE, Dávila Saldaña BJ, Thakar MS, Burroughs LM, Torgerson TR, Leiding JW, Marsh RA, Griffith LM, Pulsipher MA, Kohn DB, Notarangelo L, Cowan MJ, Puck JM, Cuvelier GDE, Heimall J, Haddad E, Pai SY, Dvorak CC.   +52 more
europepmc   +1 more source

Daily Body (Dis‐)Satisfaction and Dietary Restriction in Women Across the Eating Disorder Spectrum

International Journal of Eating Disorders, Volume 59, Issue 8, Page 1753-1763, August 2026.
ABSTRACT Objective Body dissatisfaction is a key risk factor in eating disorder development: It is theorized to promote dietary restriction, thereby contributing to symptom onset. Evidence for this pathway primarily comes from cross‐sectional or multi‐wave questionnaire studies in bulimia nervosa (BN) and anorexia nervosa (AN).
Michaela R. Buehler, Ann‐Kathrin Arend, Julia Reichenberger, Jens Blechert   +3 more
wiley   +1 more source

An update on inborn errors of V(D)J recombination. [PDF]

Physiology (Bethesda)
Schim van der Loeff I, Ahuja M, Chen R, Patane E, Hambleton S.   +4 more
europepmc   +1 more source