Results 201 to 210 of about 187,417 (303)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Disseminated BCG infection and rotavirus enteritis in an infant with severe immunodeficiency: a causal association study. [PDF]

Front Public Health
Cai J, Li S, Xu J, Li Z, Wang F, Yang L, Jia B, Bai Y, Li L.   +8 more
europepmc   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, Volume 38, Issue 26, 8 May 2026.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Mucosal B Cell Expansion and Maturation Contribute to Colitis Pathogenesis. [PDF]

Inflamm Bowel Dis
Fung ICN, Koelink PJ, Mulders LGM, Admiraal I, Verseijden C, Verhoeff J, Wildenberg ME, Luo Y, D'Haens GR, Li Yim AYF, de Jonge WJ.   +10 more
europepmc   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, Volume 13, Issue 26, 8 May 2026.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

Evolutionary insights and structural characterization guide the development of RAG1/RAG2-deficient swine models for immunological research. [PDF]

Front Immunol
Zhang R, Wu Y, Sun T, Luan T, Ren Y, Zhang Y, Lin L, Meng T, Wang J, Qiu Y.   +9 more
europepmc   +1 more source

Scid Mice [PDF]

, 2011
openaire   +1 more source

Cryptocaryone Exhibits ROS/MAPK‐Dependent Antiproliferative and Apoptosis‐Inducing Effects on Triple‐Negative Breast Cancer Cells and Proof‐of‐Concept Breast Cancer Mouse Model

Drug Development Research, Volume 87, Issue 3, May 2026.
ABSTRACT Omics’ technologies have enabled clinicians to gain previously unprecedented insights into the molecular complexity and clinical heterogeneity of triple‐negative breast cancer (TNBC). Increasingly it is being realized that TNBC does not respond well to current targeted therapies.
Ya‐Ting Chuang, Wangta Liu, Tsu‐Ming Chien, Ammad Ahmad Farooqi, Hsun‐Shuo Chang, Jun‐Ping Shiau, Hsueh‐Wei Chang   +6 more
wiley   +1 more source

SCID-Repopulating Cell [PDF]

, 2020
openaire   +1 more source

Teacher‐Led Universal Eating Disorder Prevention Programmes in Schools: A Scoping Review

European Eating Disorders Review, Volume 34, Issue 3, Page 676-721, May 2026.
ABSTRACT Objective This scoping review seeks to evaluate the efficacy of teacher‐led interventions in mitigating risk factors related to eating disorders, considering the necessity for universal prevention programmes that can be effectively administered by educators.
Jessica Parker, Lauren Makin, Karina Allen, Kate Tchanturia   +3 more
wiley   +1 more source