Severe congenital T-lymphocytopenia may affect the outcome of neonatal intensive care
Biomedical PapersAim. Circular DNA segments TREC (T-cell receptor excision circles) formed during T-lymphocyte maturation in the thymus, are a sensitive marker of thymic lymphocyte production in a broader manner.
Ivana Hulinkova +5 more
doaj +1 more source
International Journal of Neonatal Screening, 2023 Newborn screening (NBS) for Severe Combined Immunodeficiency (SCID) by measurement of T-cell receptor excision circles (TRECs) successfully identifies newborns with SCID and severe T-cell lymphopenia, as intended.
Amy Gaviglio +4 more
doaj +1 more source
Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum. [PDF]
, 2018 BACKGROUND: The study of Onchocerca volvulus has been limited by its host range, with only humans and non-human primates shown to be susceptible to the full life cycle infection.
Abraham, David +7 more
core +3 more sources
Newborn Screening for Severe Combined Immunodeficiency in Israel
International Journal of Neonatal Screening, 2017 Newborn screening (NBS) programs for severe combined immunodeficiency (SCID), the most severe type of primary immunodeficiency, are being implemented in more and more countries with every passing year.
Erez Rechavi +5 more
doaj +1 more source
RAG-1 Mutations Associated with B-Cell-Negative SCID Dissociate the Nicking and Transesterification Steps of V(D)J Recombination [PDF]
, 2001 Some patients with B-cell-negative severe combined immune deficiency (SCID) carry mutations in RAG-1 or RAG-2 that impair V(D)J recombination. Two recessive RAG-1 mutations responsible for B-cell-negative SCID, R621H and E719K, impair V(D)J recombination
Chang, Fu-Chung +2 more
core +2 more sources
Journal for ImmunoTherapy of Cancer, 2020 Background Immune compromised mice are increasingly used for the preclinical development of monoclonal antibodies (mAb). Most common are non-obese diabetic (NOD) severe combined immunodeficient (SCID) and their derivatives such as NOD SCID interleukin-2 ...
Robert J Oldham +7 more
doaj +1 more source
Cognitive behavioral group therapy versus psychoeducational intervention in Parkinson's disease [PDF]
, 2018 Objective: The aim of the current study was to evaluate whether cognitive behavioral group therapy has a positive impact on psychiatric, and motor and non-motor symptoms in Parkinson’s disease (PD).
Berardelli, Isabella +7 more
core +2 more sources
Depression and identity : Are self-constructions negative or conflictual? [PDF]
, 2017 Negative self-views have proved to be a consistent marker of vulnerability for depression. However, recent research has shown that a particular kind of cognitive conflict, implicative dilemma, is highly prevalent in depression.
Adrián Montesano +4 more
core +8 more sources
Bilateral extensive CMV retinitis in a sick child – Harbinger of severe combined immunodeficiency
Journal of Pediatric Critical Care, 2017 Cytomegalovirus (CMV) retinitis is a marker of severe cellular immunodeficiency. Severe combined immunodeficiency (SCID) must be considered in infants presenting with CMV retinitis in a non-HIV setting.
H S Vinayaka +3 more
doaj +1 more source
A murine macrofilaricide pre-clinical screening model for onchocerciasis and lymphatic filariasis
Parasites & Vectors, 2014 Background New drugs effective against adult filariae (macrofilaricides) would accelerate the elimination of lymphatic filariasis and onchocerciasis. Anti-Onchocerca drug development is hampered by the lack of a facile model. We postulated that SCID mice
Alice Halliday +13 more
doaj +1 more source