Results 41 to 50 of about 192,238 (309)
The C Terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit [PDF]
, 1999 Ku is a heterodimeric protein with double-stranded DNA end-binding activity that operates in the process of nonhomologous end joining. Ku is thought to target the DNA-dependent protein kinase (DNA-PK) complex to the DNA and, when DNA bound, can interact ...
Jeggo, P A +4 more
core +2 more sources
Recent Developments in NSG and NRG Humanized Mouse Models for Their Use in Viral and Immune Research
Viruses, 2023 Humanized mouse models have been widely used in virology, immunology, and oncology in the last decade. With advances in the generation of knockout mouse strains, it is now possible to generate animals in which human immune cells or human tissue can be ...
Maksym Kitsera +2 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Adequate thickness of the uterine lining is crucial for women with thin or damaged endometrium to achieve pregnancies. Endometrial mesenchymal stem cells (eMSC) can facilitate the cyclical repair and regeneration of the human endometrium. In this study, the human endometrium derived extracellular matrix hydrogel supports the growth of eMSC promoting ...
Jingwen Xu +9 more
wiley +1 more source
A nonsense variant of reactivation gene-1 leads to Omenn syndrome in a Pakistani family
Khyber Medical University JournalOBJECTIVE: To conduct clinical and genetic analysis in a patient with severe combined immunodeficiency disease (SCID). METHODS: A 3.5-year-old female patient with chronic diarrhea, fever, and failure to thrive was examined at the Pakistan Institute of ...
Zara Khalid +5 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel +13 more
wiley +1 more source
Depression and identity : Are self-constructions negative or conflictual? [PDF]
, 2017 Negative self-views have proved to be a consistent marker of vulnerability for depression. However, recent research has shown that a particular kind of cognitive conflict, implicative dilemma, is highly prevalent in depression.
Adrián Montesano +4 more
core +8 more sources
Frontiers in Immunology, 2020 Severe combined immunodeficiency (SCID) and other T cell lymphopenias can be detected during newborn screening (NBS) by measuring T cell receptor excision circles (TRECs) in dried blood spot (DBS) DNA. Second tier next generation sequencing (NGS) with an
Janne Strand +34 more
doaj +1 more source
Impaired bone marrow homing of cytokine-activated CD34+ cells in the NOD/SCID model [PDF]
, 2004 The reduced engraftment potential of hematopoietic stem/progenitor cells (HSPCs) after exposure to cytokines may be related to the impaired homing ability of actively cycling cells. We tested this hypothesis by quantifying the short-term horning of human
Ahmed, F +8 more
core
Geometrically Tunable Scaffold‐Free Muscle Bioconstructs for Treating Volumetric Muscle Loss
Advanced Healthcare Materials, EarlyView.Volumetric muscle loss is associated with traumatic muscle resulting in permanent functional impairment. Mold‐based, scaffold‐free, high‐density muscle tissue bioconstructs are developed in customizable geometric shapes and sizes. The transplanted rectangular solid‐shaped muscle bioconstructs improved muscle force recovery and tissue regeneration in ...
Bugra Ayan +8 more
wiley +1 more source
Establishing Newborn Screening for SCID in the USA: Experience in California
International Journal of Neonatal Screening, 2021 Newborn screening for severe combined immunodeficiency (SCID) has developed from the realization that infants affected with SCID require prompt diagnosis and treatment to avoid fatal infectious complications.
Jennifer M. Puck, Andrew R. Gennery
doaj +1 more source