Results 111 to 120 of about 63,070 (164)

The SCID–HuRAg mouse as a model for rheumatoid arthritis

Modern Rheumatology, 2001
Abstract Many animal models have been developed for a study of rheumatoid arthritis (RA). However, RA animal models are not always similar to RA patients in their response to antirheumatic drugs. Recently, humanized monoclonal antibody (mAb) has been developed for the treatment of RA, but at present there is no animal model on which to screen this mAb ...
M Uzuki, H Matsuno
exaly   +3 more sources

Development and applications of the SCID-hu mouse model

Seminars in Immunology, 1996
The SCID-hu mouse was designed to serve as a preclinical model for the analysis of human physiology and pathophysiology. In distinction to other immunodeficient mouse models, SCID-hu mice are made upon implantation of intact human organ systems rather than dispersed cell populations. Two constructs, the SCID-hu Thy/Liv and the SCID-hu Bone models, have
Joseph Mccune
exaly   +3 more sources

Humanized SCID Mouse Models for Biomedical Research

Current Topics in Microbiology and Immunology, 2008
There is a growing need for effective animal models to carry out experimental studies on human hematopoietic and immune systems without putting individuals at risk. Progress in development of small animal models for the in vivo investigation of human hematopoiesis and immunity has seen three major breakthroughs over the last three decades. First, CB 17-
Greiner D L, D L Greiner
exaly   +3 more sources

The scid Mouse Mutant

1988
The scid mutation occurred in the C.B-17Icr (C.B-17) inbred strain, an immunoglobulin heavy chain (Igh) congenic partner strain of BALB/cAnlcr (BALB/c) . The C.B-17 strain was derived from the 13th backcross generation of the original C.B stock of M. Potter.
M, Bosma, W, Schuler, G, Bosma
openaire   +2 more sources

Immunohistochemical and Ultrastructural Evidence for Myelopoiesis in the Scid/scid Mouse Thymus

The Histochemical Journal, 1999
The ultrastructure of scid mouse thymus (a small encapsulated epithelial mass within the precardial fat pad) is described. The epithelium did not form cortex or medulla and hence remained relatively undifferentiated. Small unmyelinated nerves innervated the capsule, the major blood vessels and were distributed between the epithelial cells.
M D, Kendall, D P, Lane, U, Schumacher
openaire   +2 more sources

The SCID mouse as a model for multiple myeloma

British Journal of Haematology, 1995
Summary. The SCID mouse was investigated as a potential animal model for human multiple myeloma (MM). Duplicate samples of bone marrow mononuclear cells (BMMC) and/or peripheral blood mononuclear cells (PBMC) of six MM patients in different clinical phases and one patient with monoclonal gammapathy of undetermined significance (MGUS) were injected ...
Ahsmann, E.J.M., van Tol, M.J.D., Oudeman-Gruber, J., Lokhorst, H.M., Uytdehaag, F.G.C.M., Schuurman, H.J, Bloem, A.C.   +6 more
openaire   +3 more sources

Further characterization of the radiosensitivity of the scid mouse

International Journal of Radiation Biology, 1998
To further characterize the radiation response of the scid mutation.X-ray induced chromosomal aberrations and cell killing were analysed using various in vivo or in vitro cell systems.Using low LET X-irradiation a reverse dose-rate effect was found for killing of differentiated and differentiating spermatogonia and the chromosomal hyperradiosensitivity
P P, van Buul, L, Abramsson-Zetterberg, I M, Zandman, A, van Duyn-Goedhart   +3 more
openaire   +2 more sources

THE SCID MOUSE AS A VEHICLE TO STUDY AUTOIMMUNITY

Rheumatology, 1993
Peripheral blood mononuclear cells (PBMC) injected into severe combined immune deficiency (SCID) mice continue to secrete human immunoglobulin and respond to immunization with recall antigens. PBMC for patients with autoimmune diseases produce autoantibodies of the same specificities but at lower levels compared to the donor.
K B, Elkon, D, Ashany
openaire   +2 more sources

Molecular genotyping of the mouse scid allele

Journal of Immunological Methods, 2002
Severe combined immunodeficiency (SCID) mice, which lack mature B- and T-cells, provide an important system for studies on immunity and disease. However, since the scid mutation is a single T-to-A transversion, genotypic analysis can be problematic. We have developed a rapid and simple sequence-based analysis that provides identification of both the ...
Amy L, Sealey, Nicole K, Hobbs, Edward E, Schmidt   +2 more
openaire   +2 more sources

SCID Mouse as a Model for Transplantation Studies

Journal of Surgical Research, 1996
Mice expressing the severe combined immunodeficiency trait (SCID) lack functional T and B lymphocytes and have been widely used for the study of B- cell development and for cancer and HIV research. The purpose of this study was to evaluate the SCID mouse as a potential model for T-cell maturation and transplantation studies.
J F, Renz, Z, Lin, M, de Roos, A A, Dalal, N L, Ascher   +4 more
openaire   +2 more sources