Results 1 to 10 of about 120,729 (267)
Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice. [PDF]
PLoS ONE, 2015 We have used homozygous albumin enhancer/promoter-driven urokinase-type plasminogen activator/severe combined immunodeficient (uPA/SCID) mice as hosts for chimeric mice with humanized livers.
Chise Tateno +17 more
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Recent Developments in NSG and NRG Humanized Mouse Models for Their Use in Viral and Immune Research
Viruses, 2023 Humanized mouse models have been widely used in virology, immunology, and oncology in the last decade. With advances in the generation of knockout mouse strains, it is now possible to generate animals in which human immune cells or human tissue can be ...
Maksym Kitsera +2 more
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Therapeutic efficacy of human hepatocyte transplantation in a SCID/uPA mouse model with inducible liver disease. [PDF]
PLoS ONE, 2010 Severe Combined Immune Deficient (SCID)/Urokinase-type Plasminogen Activator (uPA) mice undergo liver failure and are useful hosts for the propagation of transplanted human hepatocytes (HH) which must compete with recipient-derived hepatocytes for ...
Donna N Douglas +7 more
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Laboratory Animal Research, 2020 Genome editing has recently emerged as a powerful tool for generating mutant mice. Small deletions of nucleotides in the target genes are frequently found in CRISPR/Cas9 mediated mutant mice.
Inseon Bak +6 more
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Effects of the scid mutation on X-ray-induced deletions in the brain and spleen of gpt delta mice
Genes and Environment, 2020 Background DNA-dependent protein kinase (DNA-PK), consisting of a Ku heterodimer (Ku70/80) and a large catalytic subunit (DNA-PKcs), plays an important role in the repair of DNA double-strand breaks via non-homologous end-joining (NHEJ) in mammalian ...
Kenichi Masumura +4 more
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Comparing the MRI appearance of the lymph nodes and spleen in wild-type and immuno-deficient mouse strains. [PDF]
PLoS ONE, 2011 The goal of this study was to investigate the normal MRI appearance of lymphoid organs in immuno-competent and immuno-deficient mice commonly used in research.
Vasiliki Economopoulos +4 more
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Helicobacter-associated gastritis in SCID mice [PDF]
Infection and Immunity, 1995 Immunodeficient (SCID) and immunocompetent mice were infected with Helicobacter felis to address the role of autoimmunity in Helicobacter-associated gastritis. The extents of inflammation were equivalent in the two groups. The numbers of H. felis organisms were marginally increased in the SCID mice but did not achieve statistical significance.
T G, Blanchard +3 more
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Journal for ImmunoTherapy of Cancer, 2020 Background Immune compromised mice are increasingly used for the preclinical development of monoclonal antibodies (mAb). Most common are non-obese diabetic (NOD) severe combined immunodeficient (SCID) and their derivatives such as NOD SCID interleukin-2 ...
Robert J Oldham +7 more
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Experimental systemic cryptococcosis in SCID mice [PDF]
Medical Mycology, 1996 The susceptibility of severe combined immune deficiency (SCID) mice to experimental systemic cryptococcosis was studied. SCID mice were at least 16-fold more susceptible to lethal infection than were immunocompetent control mice (P < 0.001). Histological assessment showed that control mice responded with a granulomatous inflammatory response, whereas ...
K V, Clemons, R, Azzi, D A, Stevens
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Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK.
PLoS ONE, 2014 The noncluster homeobox gene HOX11/TLX1 (TLX1) is detected at the breakpoint of the t(10;14)(q24;q11) chromosome translocation in patients with T cell acute lymphoblastic leukemia (T-ALL).
Konstantin Krutikov +7 more
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