The SCID mouse: an experimental model for endometriosis [PDF]
Human Reproduction, 1999 The purpose of this study was to validate the suitability of the severe combined immunodeficient (SCID) mouse as an experimental model for endometriosis, by defining the morphological and histological features of induced endometrial implants, and characterizing specific biochemical properties of these implants.
K Isaacson, R A Sayegh
exaly +3 more sources
Intervention timing and disease stage shape tecovirimat and cidofovir efficacy in male SCID mice [PDF]
Nature CommunicationsCurrently, mpox virus (MPXV) continues to pose a global public health challenge, with immunocompromised individuals often exhibiting more severe clinical symptoms. This study screens three male mouse models (ICR, IFNAR1-/-, SCID) and identifies SCID mice
Xinyu Cao +12 more
doaj +2 more sources
Therapeutic efficacy of human hepatocyte transplantation in a SCID/uPA mouse model with inducible liver disease. [PDF]
PLoS ONE, 2010 Severe Combined Immune Deficient (SCID)/Urokinase-type Plasminogen Activator (uPA) mice undergo liver failure and are useful hosts for the propagation of transplanted human hepatocytes (HH) which must compete with recipient-derived hepatocytes for ...
Donna N Douglas +7 more
doaj +1 more source
The development and improvement of immunodeficient mice and humanized immune system mouse models
Frontiers in Immunology, 2022 Animal models play an indispensable role in the study of human diseases. However, animal models of different diseases do not fully mimic the complex internal environment of humans.
Jiaxuan Chen +10 more
doaj +1 more source
The use of animal models in rheumatoid arthritis research [PDF]
Journal of Yeungnam Medical Science, 2023 The pathological hallmark of rheumatoid arthritis (RA) is a synovial pannus that comprises proliferating and invasive fibroblast-like synoviocytes, infiltrating inflammatory cells, and an associated neoangiogenic response.
Jin-Sun Kong +2 more
doaj +1 more source
Comparing the MRI appearance of the lymph nodes and spleen in wild-type and immuno-deficient mouse strains. [PDF]
PLoS ONE, 2011 The goal of this study was to investigate the normal MRI appearance of lymphoid organs in immuno-competent and immuno-deficient mice commonly used in research.
Vasiliki Economopoulos +4 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2020 Background Immune compromised mice are increasingly used for the preclinical development of monoclonal antibodies (mAb). Most common are non-obese diabetic (NOD) severe combined immunodeficient (SCID) and their derivatives such as NOD SCID interleukin-2 ...
Robert J Oldham +7 more
doaj +1 more source
Non-viral ex vivo genome-editing in mouse bona fide hematopoietic stem cells with CRISPR/Cas9
Molecular Therapy: Methods & Clinical Development, 2021 We conducted two lines of genome-editing experiments of mouse hematopoietic stem cells (HSCs) with the clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated protein 9 (Cas9).
Suvd Byambaa +6 more
doaj +1 more source
Efficient derivation of extended pluripotent stem cells from NOD-scid Il2rg −/− mice
Protein & Cell, 2018 Recently we have established a new culture condition enabling the derivation of extended pluripotent stem (EPS) cells, which, compared to conventional pluripotent stem cells, possess superior developmental potential and germline competence.
Yaqin Du +12 more
doaj +1 more source
Development of a model for marburgvirus based on severe-combined immunodeficiency mice
Virology Journal, 2007 The filoviruses, Ebola (EBOV) and Marburg (MARV), cause a lethal hemorrhagic fever. Human isolates of MARV are not lethal to immmunocompetent adult mice and, to date, there are no reports of a mouse-adapted MARV model. Previously, a uniformly lethal EBOV-
Kalina Warren V +7 more
doaj +1 more source