Results 31 to 40 of about 63,070 (164)

Establishment of Orthotopic Xuanwei Lung Cancer SCID Mouse Model 
and Analysis of Biological Properties

Chinese Journal of Lung Cancer, 2012
Background and objective The incidence of Xuanwei lung cancer ranks first in China, and its pathogenesis requires in-depth investigation. This study aims to establish an orthotopic Xuanwei lung cancer severe combined immunodeficiency (SCID) mouse model ...
Yongchun ZHOU, Yan CHEN, Xicai WANG, Xin LIU, Hutao SHI, Qian YAO, Congguo JIN, Zhiping WU, Yunchao HUANG   +8 more
doaj   +1 more source

SCID Mouse Model for Lethal Q Fever [PDF]

Infection and Immunity, 2003
ABSTRACTQ fever, a worldwide zoonosis caused byCoxiella burnetii, has many manifestations in humans. Endocarditis is the most serious complication of Q fever. Animal models are limited to acute pulmonary or hepatic disease and reproductive disorders. An appropriate experimental animal model for Q fever endocarditis does not yet exist.
Masako, Andoh, Takashi, Naganawa, Akitoyo, Hotta, Tsuyoshi, Yamaguchi, Hideto, Fukushi, Toshiaki, Masegi, Katsuya, Hirai   +6 more
openaire   +2 more sources

Development of Severe Combined Immunodeficient (SCID) Pig Models for Translational Cancer Modeling: Future Insights on How Humanized SCID Pigs Can Improve Preclinical Cancer Research

Frontiers in Oncology, 2018
Within the last decade there have been several severe combined immunodeficient (SCID) pig models discovered or genetically engineered. The animals have mutations in ARTEMIS, IL2RG, or RAG1/2 genes, or combinations thereof, providing SCID pigs with NK ...
Adeline N. Boettcher, Crystal L. Loving, Joan E. Cunnick, Christopher K. Tuggle   +3 more
doaj   +1 more source

Splicing factor arginine/serine‐rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome‐based cellular communication

Clinical and Translational Medicine, 2022
Background Multiple myeloma (MM) is a distinctive malignancy of plasma cell within the bone marrow (BM), of which alternative splicing factors play vital roles in the progression.
Yuanjiao Zhang, Xichao Yu, Rongze Sun, Jie Min, Xiaozhu Tang, Zigen Lin, Siyuan Xie, Xinying Li, Shengfeng Lu, Zhidan Tian, Chunyan Gu, Lesheng Teng, Ye Yang   +12 more
doaj   +1 more source

Application of functional genomics to the chimeric mouse model of HCV infection: optimization of microarray protocols and genomics analysis

Virology Journal, 2006
Background Many model systems of human viral disease involve human-mouse chimeric tissue. One such system is the recently developed SCID-beige/Alb-uPA mouse model of hepatitis C virus (HCV) infection which involves a human-mouse chimeric liver.
Smith Maria W, Wallace James, Proll Sean, Thompson Jill C, Joyce Michael A, Walters Kathie-Anne, Furlong Jeff, Tyrrell D Lorne, Katze Michael G   +8 more
doaj   +1 more source

Gene therapy model of X-linked severe combined immunodeficiency using a modified foamy virus vector. [PDF]

PLoS ONE, 2013
X-linked severe combined immunodeficiency (SCID-X1) is an inherited genetic immunodeficiency associated with mutations in the common cytokine receptor γ chain (γc) gene, and characterized by a complete defect of T and natural killer (NK) cells.
Satoshi Horino, Toru Uchiyama, Takanori So, Hiroyuki Nagashima, Shu-Lan Sun, Miki Sato, Atsuko Asao, Yoichi Haji, Yoji Sasahara, Fabio Candotti, Shigeru Tsuchiya, Shigeo Kure, Kazuo Sugamura, Naoto Ishii   +13 more
doaj   +1 more source

Adult Human Liver Mesenchymal Stem/Progenitor Cells Participate in Mouse Liver Regeneration after Hepatectomy

Cell Transplantation, 2013
The advances in stem cell science have promoted research on their use in liver regenerative medicine. Beyond the demonstration of their ability to display metabolic functions in vitro, candidate cells should demonstrate achievable in situ differentiation
Dung Ngoc Khuu, Omar Nyabi, Cédric Maerckx, Etienne Sokal, Mustapha Najimi Ph.D.   +4 more
doaj   +1 more source

Higher susceptibility of NOD/LtSz-scid Il2rg-/- NSG mice to xenotransplanted lung cancer cell lines

Cancer Management and Research, 2014
Nobuhiro Kanaji,1 Akira Tadokoro,1 Kentaro Susaki,1 Saki Yokokura,1 Kiyomi Ohmichi,2 Reiji Haba,2 Naoki Watanabe,1 Shuji Bandoh,1 Tomoya Ishii,1 Hiroaki Dobashi,1 Takuya Matsunaga11Department of Internal Medicine, Division of Hematology, Rheumatology and
Kanaji N, Tadokoro A, Susaki K, Yokokura S, Ohmichi K, Haba R, Watanabe N, Bandoh S, Ishii T, Dobashi H, Matsunaga T   +10 more
doaj  

Validation of ultrasound bioimaging to predict worm burden and treatment efficacy in preclinical filariasis drug screening models

Scientific Reports, 2018
Filariasis is a global health problem targeted for elimination. Curative drugs (macrofilaricides) are required to accelerate elimination. Candidate macrofilaricides require testing in preclinical models of filariasis.
Amy E. Marriott, Hanna Sjoberg, Hayley Tyrer, Joanne Gamble, Emma Murphy, John Archer, Andrew Steven, Mark J. Taylor, Joseph D. Turner   +8 more
doaj   +1 more source

The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts

Arthritis Research & Therapy, 2019
Background Activin A and follistatin exhibit immunomodulatory functions, thus affecting autoinflammatory processes as found in rheumatoid arthritis (RA).
Magnus Diller, Klaus Frommer, Berno Dankbar, Ingo Tarner, Marie-Lisa Hülser, Lali Tsiklauri, Rebecca Hasseli, Michael Sauerbier, Thomas Pap, Stefan Rehart, Ulf Müller-Ladner, Elena Neumann   +11 more
doaj   +1 more source