Results 41 to 50 of about 63,070 (164)

Biosafety Studies of a Clinically Applicable Lentiviral Vector for the Gene Therapy of Artemis-SCID

Molecular Therapy: Methods & Clinical Development, 2019
Genetic deficiency of the nuclease DCLRE1C/Artemis causes radiosensitive severe combined immunodeficiency (RS-SCID) with lack of peripheral T and B cells and increased sensitivity to ionizing radiations.
Sabine Charrier, Chantal Lagresle-Peyrou, Valentina Poletti, Michael Rothe, Grégory Cédrone, Bernard Gjata, Fulvio Mavilio, Alain Fischer, Axel Schambach, Jean-Pierre de Villartay, Marina Cavazzana, Salima Hacein-Bey-Abina, Anne Galy   +12 more
doaj   +1 more source

A radiolabeled antibody targeting CD123+ leukemia stem cells – initial radioimmunotherapy studies in NOD/SCID mice engrafted with primary human AML

Leukemia Research Reports, 2015
Radioimmunotherapy (RIT) with anti-CD123 monoclonal antibody CSL360 modified with nuclear translocation sequence (NLS) peptides and labeled with the Auger electron-emitter, 111In (111In-NLS-CSL360) was studied in the prevalent NOD/SCID mouse AML ...
Jeffrey V. Leyton, Catherine Gao, Brent Williams, Armand Keating, Mark Minden, Raymond M. Reilly   +5 more
doaj   +1 more source

Autonomous growth potential of leukemia blast cells is associated with poor prognosis in human acute leukemias

Journal of Hematology & Oncology, 2009
We have described a severe combined immunodeficiency (SCID) mouse model that permits the subcutaneous growth of primary human acute leukemia blast cells into a measurable subcutaneous nodule which may be followed by the development of disseminated ...
Jakubowski Ann A, Guan Xiuqin, Wieman Eric A, Yan Ying, Steinherz Peter G, O'Reilly Richard J   +5 more
doaj   +1 more source

Reference genomes for BALB/c Nude and NOD/SCID mouse models. [PDF]

G3 (Bethesda), 2023
Schmid-Siegert E, Qin M, Tian H, Arpat B, Chen B, Xenarios I.   +5 more
europepmc   +1 more source

Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence

Emerging Microbes and Infections, 2019
Enterovirus A71 (EV-A71) is one of the main causative agents of hand-foot-and-mouth disease and is occasionally associated with severe neurological complications.
Liang Sun, Aloys Tijsma, Carmen Mirabelli, Jim Baggen, Maryam Wahedi, David Franco, Armando De Palma, Pieter Leyssen, Erik Verbeken, Frank J. M. van Kuppeveld, Johan Neyts, Hendrik Jan Thibaut   +11 more
doaj   +1 more source

Deciphering reproductive aging in women using a NOD/SCID mouse model for distinct physiological ovarian phenotypes. [PDF]

Aging (Albany NY), 2023
Marchante M, Ramirez-Martin N, Buigues A, Martinez J, Pellicer N, Pellicer A, Herraiz S.   +6 more
europepmc   +1 more source

Evaluation of the NOD/SCID xenograft model for glucocorticoid-regulated gene expression in childhood B-cell precursor acute lymphoblastic leukemia

BMC Genomics, 2011
Background Glucocorticoids such as prednisolone and dexamethasone are critical drugs used in multi-agent chemotherapy protocols used to treat acute lymphoblastic leukemia (ALL), and response to glucocorticoids is highly predictive of outcome.
Bhadri Vivek A, Cowley Mark J, Kaplan Warren, Trahair Toby N, Lock Richard B   +4 more
doaj   +1 more source

A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 Infection. [PDF]

J Virol, 2022
Abdelnabi R, Foo CS, Kaptein SJF, Boudewijns R, Vangeel L, De Jonghe S, Jochmans D, Weynand B, Neyts J.   +8 more
europepmc   +1 more source

Cure of Micrometastatic B-Cell Lymphoma in a SCID Mouse Model Using ²¹³Bi-Anti-CD20 Monoclonal Antibody. [PDF]

J Nucl Med, 2023
Havlena GT, Kapadia NS, Huang P, Song H, Engles J, Brechbiel M, Sgouros G, Wahl RL.   +7 more
europepmc   +1 more source

A SCID mouse-human lung xenograft model of SARS-CoV-2 infection. [PDF]

Theranostics, 2021
Fu W, Wang W, Yuan L, Lin Y, Huang X, Chen R, Cai M, Liu C, Chen L, Zhou M, Wu K, Zhao H, Pan D, Ma J, Hong J, Zhai B, Zhang Y, Kong Z, Wang Y, Chen Y, Yuan Q, Zhu H, Cheng T, Guan Y, Xia N.   +24 more
europepmc   +1 more source