Results 21 to 30 of about 63,070 (164)

The utilization of humanized mouse models for the study of human retroviral infections

Retrovirology, 2009
The development of novel techniques and systems to study human infectious diseases in both an in vitro and in vivo settings is always in high demand. Ideally, small animal models are the most efficient method of studying human afflictions.
Saifuddin Mohammed, Kehn-Hall Kylene, Carpio Lawrence, Guendel Irene, Pedati Caitlin, Van Duyne Rachel, Kashanchi Fatah   +6 more
doaj   +1 more source

Insights from engraftable immunodeficient mouse models of hyperinsulinaemia

Scientific Reports, 2017
Hyperinsulinaemia, obesity and dyslipidaemia are independent and collective risk factors for many cancers. Here, the long-term effects of a 23% Western high-fat diet (HFD) in two immunodeficient mouse strains (NOD/SCID and Rag1 −/−) suitable for ...
Michelle L. Maugham, Patrick B. Thomas, Gabrielle J. Crisp, Lisa K. Philp, Esha T. Shah, Adrian C. Herington, Chen Chen, Laura S. Gregory, Colleen C. Nelson, Inge Seim, Penny L. Jeffery, Lisa K. Chopin   +11 more
doaj   +1 more source

Outcome of Xenografted Fetal Porcine Pancreatic Tissue is Superior in Inbred Scid (C.B-17/Icr-scid/scid) Compared to Outbred Nude (CD-1-nu/nu) Mice

Cell Transplantation, 1999
Nude mice are used as recipients of foreign tissue because of their inability to reject these grafts. Our experience has been that there is variable rejection of fetal porcine insulin-producing tissue transplanted into CD-1 (athymic) outbred nude mice ...
Bernard E. Tuch Ph.D., Frances M. Casamento   +1 more
doaj   +1 more source

Angiopoietin 2 alters pancreatic vascularization in diabetic conditions. [PDF]

PLoS ONE, 2012
AIMS/HYPOTHESIS: Islet vascularization, by controlling beta-cell mass expansion in response to increased insulin demand, is implicated in the progression to glucose intolerance and type 2 diabetes. We investigated how hyperglycaemia impairs expansion and
Sophie Calderari, Cécile Chougnet, Maud Clemessy, Hervé Kempf, Pierre Corvol, Etienne Larger   +5 more
doaj   +1 more source

Rescue of Fertility in Homozygous Mice for the Urokinase Plasminogen Activator Transgene by the Transplantation of Mouse Hepatocytes

Cell Transplantation, 2008
Development of the urokinase plasminogen activator/SCID (uPA/SCID) transgenic mouse model has opened new perspectives for the study of different biological mechanisms such as liver regeneration, stem cell differentiation, and human hepatic pathogens.
Nicolas M. Brezillon, Lucie Dasilva, David L'hôte, Florence Bernex, Julie Piquet, Nadine Binart, Serban Morosan, Dina Kremsdorf   +7 more
doaj   +1 more source

Transplacental murine cytomegalovirus infection in the brain of SCID mice

Virology Journal, 2007
Background Congenital cytomegalovirus (CMV) infection is the most common congenital viral infection in humans and the major nonhereditary cause of central nervous system (CNS) developmental disorders.
Jaquish Dawn V, Woolf Nigel K, Koehrn Fred J   +2 more
doaj   +1 more source

Effects of the scid mutation on X-ray-induced deletions in the brain and spleen of gpt delta mice

Genes and Environment, 2020
Background DNA-dependent protein kinase (DNA-PK), consisting of a Ku heterodimer (Ku70/80) and a large catalytic subunit (DNA-PKcs), plays an important role in the repair of DNA double-strand breaks via non-homologous end-joining (NHEJ) in mammalian ...
Kenichi Masumura, Fumio Yatagai, Masako Ochiai, Hitoshi Nakagama, Takehiko Nohmi   +4 more
doaj   +1 more source

Development of a novel rodent model for dog heartworm microfilaremia using the severe-combined immunodeficiency mouse

Scientific Reports
Dirofilaria immitis is a mosquito-borne parasitic nematode that causes fatal heartworm disease in canids. The microfilariae are essential for research, including drug screening and mosquito-parasite interactions.
Mihoko Mizuseki, Nao Ikeda, Takahiro Shirozu, Maki Yamagishi, Sugao Oshiro, Shinya Fukumoto   +5 more
doaj   +1 more source

Immunodeficiency Promotes Adaptive Alterations of Host Gut Microbiome: An Observational Metagenomic Study in Mice

Frontiers in Microbiology, 2019
The crosstalk between the gut microbiota and immune state of the host is an essential focus in academia and clinics. To explore the dynamic role of the microbiota in response to immune deficiency, we comprehensively assessed the microbiome of 90 mouse ...
Shuyu Zheng, Shuyu Zheng, Tingting Zhao, Shuijuan Yuan, Lingyu Yang, Jinmei Ding, Li Cui, Mingqing Xu   +7 more
doaj   +1 more source

Effect of Oxymatrine Combined with Low Dose 5-FU on Lymphatic Vessel and Microvascular Endothelial Cell Growth of Gastric Cancer in a Severe Combined Immunodeficient Mouse Orthotopic Implantation Model

European Journal of Inflammation, 2011
In this study, we explored the effect of Oxymatrine combined with low dose 5-Fu on lymphatic vessel and vascular endothelial growth factor of orthotopic implantated gastric cancer in severe combined immunodeficient (SCID) nude mice.
J-S. Zhu, Z-P. Xu, M-Q. Song, Q. Zhang
doaj   +1 more source