Results 11 to 20 of about 63,070 (164)

Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice. [PDF]

PLoS ONE, 2015
We have used homozygous albumin enhancer/promoter-driven urokinase-type plasminogen activator/severe combined immunodeficient (uPA/SCID) mice as hosts for chimeric mice with humanized livers.
Chise Tateno, Yosuke Kawase, Yoshimi Tobita, Satoko Hamamura, Hiroki Ohshita, Hiroshi Yokomichi, Harumi Sanada, Masakazu Kakuni, Akira Shiota, Yuha Kojima, Yuji Ishida, Hiroshi Shitara, Naoko A Wada, Hiromi Tateishi, Masayuki Sudoh, Shin-Ichiro Nagatsuka, Kou-Ichi Jishage, Michinori Kohara   +17 more
doaj   +1 more source

The TLR3 Agonist Poly Inosinic:Cytidylic Acid Significantly Augments the Therapeutic Activity of an Anti-CD7 Immunotoxin for Human T-Cell Leukaemia

Biomedicines, 2019
We have previously shown that antibody-dependent cellular cytotoxicity (ADCC) cooperates with immunotoxin (IT)-mediated killing of human leukaemia cells in an severe combined immunodeficient (SCID) mouse model of human T-cell acute lymphoblastic ...
David J. Flavell, Suzanne E. Holmes, Sarah L Warnes, Sopsamorn U. Flavell   +3 more
doaj   +1 more source

Increased γ-H2A.X intensity in response to chronic medium-dose-rate γ-ray irradiation. [PDF]

PLoS ONE, 2012
BACKGROUND: The molecular mechanisms of DNA repair following chronic medium-dose-rate (MDR) γ-ray-induced damage remain largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: We used a cell function imager to quantitatively measure the fluorescence intensity ...
Takashi Sugihara, Hayato Murano, Kimio Tanaka   +2 more
doaj   +1 more source

Possibility of using a mouse SCID as a model animal to variola virus for evaluating anti-smallpox drug efficacy

Вавиловский журнал генетики и селекции, 2015
At present, there is no animal model for smallpox that reflects the weakened immune system in people and can therefore help assess the prophylactic (highly preventive) efficiency of antiviral drugs. To fill in the gap, we have explored the possibility of
K. A. Titova, Al. A. Sergeev, A. S. Kabanov, L. E. Bulychev, Ar. A. Sergeev, D. O. Galahova, A. S. Zamedyanskaya, L. N. Shishkina, O. S. Taranov, V. V. Omigov, E. L. Zavjalov, A. P. Agafonov, A. N. Sergeev   +12 more
doaj   +1 more source

Visualizing the prostate gland by MR imaging in young and old mice. [PDF]

PLoS ONE, 2013
Prostate imaging requires optimization in young and old mouse models. We tested which MR sequences and field strengths best depict the prostate gland in young and old mice; and, whether prostate MR signal, size, and architecture change with age.Magnetic ...
Murali Ravoori, Jyoti Duggal, Mihai Gagea, Lin Han, Sheela Singh, Ping Liu, Wei Wei, Dustin K Ragan, James A Bankson, Jingfei Ma, Vikas Kundra   +10 more
doaj   +1 more source

The Kinetics of SCID-hu Reconstitution: A Comparison between Human Splenocytes and Peripheral Blood Leucocytes

Cell Transplantation, 1993
Although preliminary studies have shown that the severely combined immunodeficient (SCID)-hu mouse can reject allo tissue, they have also highlighted the current limitations of the SCID-hu model.
Stephen M. Thirdborough, Julie C. Chamberlain, Sue M. Swift, Roger F. L. James, Nicholas J. M. London   +4 more
doaj   +1 more source

ARG098, a novel anti-human Fas antibody, suppresses synovial hyperplasia and prevents cartilage destruction in a severe combined immunodeficient-HuRAg mouse model

BMC Musculoskeletal Disorders, 2010
Background The anti-human Fas/APO-1/CD95 (Fas) mouse/human chimeric monoclonal IgM antibody ARG098 (ARG098) targets the human Fas molecule. The cytotoxic effects of ARG098 on cells isolated from RA patients, on normal cells in vitro, and on RA synovial ...
Matsubara Tsukasa, Funahashi Keiko, Nishioka Kusuki, Nakamura Hiroshi, Katsuta Osamu, Takai-Imamura Miwa, Odani-Kawabata Noriko, Sasano Minoru, Aono Hiroyuki   +8 more
doaj   +1 more source

Human-derived IgG level as an indicator for EBV-associated lymphoma model in Hu-PBL/SCID chimeras

Virology Journal, 2011
Background Epstein-Barr virus (EBV) has a close association with various types of human lymphomas. Animal models are essential to elucidate the pathogenesis of human EBV-associated lymphomas.
Cheng Ailan, Liu Fang, Zhang Yang, He Rongfang, Tang Yunlian, Wu Yimou, Gan Runliang   +6 more
doaj   +1 more source

CD27, CD201, FLT3, CD48, and CD150 cell surface staining identifies long-term mouse hematopoietic stem cells in immunodeficient non-obese diabetic severe combined immune deficient-derived strains

Haematologica, 2020
Staining for CD27 and CD201 (endothelial protein C receptor) has been recently suggested as an alternative to stem cell antigen–1 (Sca1) to identify hematopoietic stem cells in inbred mouse strains with low or nil expression of SCA1.
Bianca Nowlan, Elizabeth D. Williams, Michael R. Doran, Jean-Pierre Levesque   +3 more
doaj   +1 more source

Animal Models of Multiple Myeloma Bone Disease

Frontiers in Genetics, 2021
Multiple myeloma (MM) is a clonal B-cell disorder characterized by the proliferation of malignant plasma cells (PCs) in the bone marrow, the presence of monoclonal serum immunoglobulin, and osteolytic lesions.
Syed Hassan Mehdi, Sana Nafees, Syed Jafar Mehdi, Carol A. Morris, Ladan Mashouri, Donghoon Yoon   +5 more
doaj   +1 more source