Results 21 to 30 of about 120,729 (267)

Differentiation of Uterine Natural Killer Cells in Pregnant SCID (scid/scid) Mice

Journal of Veterinary Medical Science, 2011
To determine whether functional T- and B-cells can affect differentiation and/or proliferation of uterine natural killer (uNK) cells, their numbers in SCID mice (genotype, C.B.-17/Icr-scid/scid) were compared with those of control mice (genotype, C.B.-17/Icr-+/+) on days 8, 12 and 16 of pregnancy.
Masato, Hiyama, Ken Takeshi, Kusakabe, Ai, Kuwahara, Shoichi, Wakitani, Hamayun, Khan, Yasuo, Kiso   +5 more
openaire   +3 more sources

Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID

Molecular Therapy: Methods & Clinical Development, 2020
Recombinase-activating gene-1 (RAG1)-deficient severe combined immunodeficiency (SCID) patients lack B and T lymphocytes due to the inability to rearrange immunoglobulin and T cell receptor genes.
Laura Garcia-Perez, Marja van Eggermond, Lieke van Roon, Sandra A. Vloemans, Martijn Cordes, Axel Schambach, Michael Rothe, Dagmar Berghuis, Chantal Lagresle-Peyrou, Marina Cavazzana, Fang Zhang, Adrian J. Thrasher, Daniela Salvatori, Pauline Meij, Anna Villa, Jacques J.M. Van Dongen, Jaap-Jan Zwaginga, Mirjam van der Burg, H. Bobby Gaspar, Arjan Lankester, Frank J.T. Staal, Karin Pike-Overzet   +21 more
doaj   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Outcome of Xenografted Fetal Porcine Pancreatic Tissue is Superior in Inbred Scid (C.B-17/Icr-scid/scid) Compared to Outbred Nude (CD-1-nu/nu) Mice

Cell Transplantation, 1999
Nude mice are used as recipients of foreign tissue because of their inability to reject these grafts. Our experience has been that there is variable rejection of fetal porcine insulin-producing tissue transplanted into CD-1 (athymic) outbred nude mice ...
Bernard E. Tuch Ph.D., Frances M. Casamento   +1 more
doaj   +1 more source

SCID-bg mice as xenograft recipients [PDF]

Laboratory Animals, 1997
SCID- bg ( scid/scid, beige/beige) is a strain of double-mutant mice with impaired lymphoid development and reduced natural killer (NK) cell activity. The present study was undertaken to evaluate the usefulness of SCID- bg mice as xenograft recipients.
S, Shibata, T, Asano, A, Ogura, N, Hashimoto, J, Hayakawa, K, Uetsuka, H, Nakayama, K, Doi   +7 more
openaire   +2 more sources

Data in support of the bone analysis of NOD–SCID mice treated with zoledronic acid and prednisolone

Data in Brief, 2016
This paper reports data on the bone, specifically the tibia and mandible, of nonobese diabetic mice with severe combined immunodeficiency disease (NOD–SCID mice) treated with zoledronic acid (ZA) and prednisolone (PSL).
Naoko Hori, Takahiro Abe, Tsuyoshi Sato, Shoichiro Kokabu, Yumiko Shimamura, Tomoya Sato, Tetsuya Yoda   +6 more
doaj   +1 more source

Repurposing Hetrombopag for Multiple Myeloma by Targeting PNPO: A Celastrol-Inspired Approach. [PDF]

Basic Clin Pharmacol Toxicol
Hetrombopag targeted PNPO to inhibit multiple myeloma. ABSTRACT Multiple myeloma (MM) is a malignancy of plasma cells whose excessive immunoglobulin production elevates reactive oxygen species (ROS), promoting pathogenesis. Active compounds from Traditional Chinese Medicine, such as celastrol, can exert antitumour effects by further increasing ROS ...
Yu T, Wang C, Xie J, Wei Y, Cui H, Zhang H, Zhou F, Deng Z, Yang Y, Gu C.   +9 more
europepmc   +2 more sources

Facilitated engraftment of human hematopoietic cells in severe combined immunodeficient mice following a single injection of Cl²MDP liposomes [PDF]

, 1997
Transplantation of normal and malignant human hematopoietic cells into severe combined immunodeficient (SCID) mice allows for evaluation of long-term growth abilities of these cells and provides a preclinical model for therapeutic interventions. However,
Bos, K van den, Leenen, P.J.M., Loenen, W.A.M., Löwenberg, B., Prins, A., Rooijen, N. van, Terpstra, W., Verstegen, M.M.A., Wagemaker, G., Wielenga, J.J., Wijngaardt, S. van, Wognum, A.W.   +11 more
core   +3 more sources

Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA. [PDF]

, 2001
Long-term expression of coagulation factor IX (FIX) has been observed in murine and canine models following administration of recombinant adeno-associated viral (rAAV) vectors into either the portal vein or muscle. These studies were designed to evaluate
Davidoff, A, Hanawa, H, Nathwani, AC, Nienhuis, AW, Vanin, EF, Zhou, JF   +5 more
core   +1 more source

Dengue Fever in Humanized NOD/SCID Mice [PDF]

Journal of Virology, 2005
ABSTRACT The increased transmission and geographic spread of dengue fever (DF) and its more severe presentation, dengue hemorrhagic fever (DHF), make it the most important mosquito-borne viral disease of humans (50 to 100 million infections/year) (World Health Organization, Fact sheet 117, 2002).
Dennis A, Bente, Michael W, Melkus, J Victor, Garcia, Rebeca, Rico-Hesse   +3 more
openaire   +2 more sources