Results 161 to 170 of about 2,250,027 (306)
Forum: Qualitative Social Research, 2002 I argue that reflexivity should not be seen as being primarily about the relationship of scientific writing to the realities studied—as it is often understood.
Tarja Knuuttila
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Schlüsselwerke der Science & Technology Studies
, 2014 Die Science & Technology Studies sind ein interdisziplinäres und vor allem internationales Forschungsfeld, das sich mit den Wechselverhältnissen von Wissenschaft, Technik und Gesellschaft beschäftigt.
Lengersdorf, Diana, Wieser, Matthias
core
The ethics of science journalism in medicine: a science and technology studies approach. [PDF]
J Med Ethics Hist MedSharifzadeh R.
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Catalan Association for Science and Technology Studies (STS-CAT) is born
The EASST Review is a quarterly open access publication that has followed developments in our field for more than 30 years. If you are interested in contributing to EASST Review, we have a rolling deadline, and any submission will go into the next issue.
Aibar, Eduard +2 more
core
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Gaston Bachelard's scientific philosophy: an approach to science and technology studies
, 2009 The contributions of Gaston Bachelard to the history and philosophy of science are not very well known in the United States. This thesis traces the particular characteristics of Bachelard's epistemology within the context of early twentieth century ...
Pereira, Maria Teresa Castelao
core
Integrating 4E cognition with science and technology studies: a framework for understanding AI applications. [PDF]
Front Artif IntellGahrn-Andersen R.
europepmc +1 more source