Results 121 to 130 of about 14,333,906 (401)

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

open access: yesMolecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo   +8 more
wiley   +1 more source

Smart Blockchain Badges for Data Science Education

open access: yesFrontiers in Education Conference, 2018
Blockchain technology has the potential to revolutionise education in a number of ways. In this paper, we explore the applications of Smart Blockchain Badges on data science education. In particular, we investigate how Smart Blockchain Badges can support
A. Mikroyannidis   +3 more
semanticscholar   +1 more source

Quantum Science and Technologies in K-12: Supporting Teachers to Integrate Quantum in STEM Classrooms

open access: yesEducation Sciences
Quantum science and computing represent a vital intersection between science and technology, gaining increasing importance in modern society. There is a pressing need to incorporate these concepts into the K-12 curriculum, equipping new generations with ...
Nancy Holincheck   +5 more
doaj   +1 more source

Instructional Materials and Implementation of Next Generation Science Standards: Demand, Supply, and Strategic Opportunities [PDF]

open access: yes, 2017
Next Generation Science Standards (NGSS) are in demand, but the supply of high quality K-12 instructional materials in science is lacking. This disconnect comes at a critical time in the implementation of new science standards, which are now influencing ...
Christine Chopyak, Rodger Bybee
core  

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Science, TV and education: active, not passive learning at a distance? [PDF]

open access: yes, 2006
Talk to scientists, broadcasters, educationalists or those working for the public understanding of science and you will get, almost certainly, a view that science has a declining presence in the output of major broadcasters.
Robinson, David
core  

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

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