Results 141 to 150 of about 14,333,906 (401)

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Importance of pre-school science education

open access: yesSHS Web of Conferences, 2017
Considering this aspect of the study, the objective of the study is determining the importance of science education in pre-school period. In this research, two open-ended questions were asked to the prospective teachers. In these questions, the focus was
Kaçan Sibel Demir, Çelikler Dilek
doaj   +1 more source

Experiences and opportunities in teaching ukrainian students at the faculty of mining and geoengineering in AGH University of Science and Technology [PDF]

open access: yes, 2018
The paper presents the influence of various factors on the process of internationalisation of higher education in Poland, and particularly in AGH University of Science and Technology from the perspective of the Faculty of Mining and ...
Borowski, M., Сala, M.
core  

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

The role of the research and education center «science education» in training natural science teachers

open access: yesВысшее образование в России, 2022
In modern conditions, educational institutions should provide the future natural science teachers with a deep fundamental training in physics, chemistry and biology.
Olga S. Shubinа, Natalia A. Melnikova
doaj  

Interview with Marianne Marcus [PDF]

open access: yes, 2016
An oral history with Marianne Marcus, Professor Emerita at the University of Texas at Houston School of Nursing. Before she retired and assumed the title of Professor Emerita in 2104, Dr.
Marcus, Marianne, EdD, RN
core   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

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