Results 81 to 90 of about 13,936,565 (355)
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Career-related learning and science education: the changing landscape [PDF]
, 2012 Pupils ask STEM subject teachers about jobs and careers in science, but where else do they learn about work? This article outlines career-related learning within schools in England alongside other factors that influence pupils’ career decisions.
Hutchinson, Jo
core +1 more source
SCIENCE VERSUS SCIENCE EDUCATION [PDF]
GAMTAMOKSLINIS UGDYMAS / NATURAL SCIENCE EDUCATION, 2012 Scientific process consists in multiple repetitions of researches in order to verify their results. They are also publicized and undergo the process of criticism and evaluation by the scientific community. The science is the social process in which the scientists con-stantly look at the results of the others’ work, accept them or reject based on the ...
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Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Math and Science Education Focus Groups: Summary [PDF]
, 2005 Summarizes the causes of low achievement in math and science and strategies for raising student interest, enhancing teacher quality and professional development, and improving curricula and teaching strategies, as discussed at a November 2004 ...
core
SCIENCE, AND EDUCATIONAL RECONSTRUCTION [PDF]
Textile Institute. Journal. Proceedings and Abstracts, 1918 n ...
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Smart Blockchain Badges for Data Science Education
Frontiers in Education Conference, 2018 Blockchain technology has the potential to revolutionise education in a number of ways. In this paper, we explore the applications of Smart Blockchain Badges on data science education. In particular, we investigate how Smart Blockchain Badges can support
A. Mikroyannidis +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source