Results 201 to 210 of about 2,545,043 (343)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Global research trends on physical education practices: a bibliometric analysis and science-mapping study. [PDF]

Front Sports Act Living
Hernández-González V, Carné-Torrent JM, Jové-Deltell C, Reverter-Masia J.   +3 more
europepmc   +1 more source

Bibliometric Computational Mapping Analysis of Publications on Environmental Science-Based Product Design using VOSviewer

Handayani Madania Insani, Afifah Mu’minah, Meita Annisa Nurhutami, R. Moch . Rizal Hafiyan   +3 more
openalex   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Global output of clinical application research on artificial intelligence in the past decade: a scientometric study and science mapping. [PDF]

Syst Rev
Shi JY, Yue SJ, Chen HS, Fang FY, Wang XL, Xue JJ, Zhao Y, Li Z, Sun C.   +8 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Science mapping of COVID-19 contributions in primary health care by OECD countries: A machine learning approach. [PDF]

Digit Health
Damar M, Hosseini B, Pinto AD, Aydin O, Cali U.   +4 more
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Science mapping analysis of embodied energy in the construction industry

, 2021
Mohamed Marzouk, Nehal Elshaboury
openalex   +1 more source

Science Mapping Artificial Intelligence

, 2018
Mediante science mapping, se muestra la visualización de la estructura intelectual de la inteligencia artificial, a nivel mundial. Se identifican sus principales líneas de investigación a partir de las citas de sus trabajos, como interactúan entre sí, mediante la detección de los nodos con un alto grado de centralidad de betweenness o intermediación ...
Vargas-Quesada, Benjamín, Chinchilla-Rodríguez, Zaida, Perianes-Rodríguez, Antonio   +2 more
openaire   +1 more source