Results 141 to 150 of about 7,192,706 (393)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

5. Athens: Plato

, 1958
Plato (427-347 B. C.) was born to a distinguished Athenian family a few years after the beginning of the Peloponnesian War. He came under the influence of Socrates, although he may not have been one of the philosopher\u27s most intimate followers.
Bloom, Robert L., Crapster, Basil L., Dunkelberger, Harold A., Glatfelter, Charles H., Mara, Richard T., Richardson, Norman E., Schubart, W. Richard   +6 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

President Trump's war on regulatory science [PDF]

, 2019
The Trump Administration has taken numerous actions that appear hostile to scientists, scientific research, and scientific data, leading some observers to assert that a war on science is underway.
Lin, AC
core  

Mysticism and Science: The Amalgam Wars [PDF]

, 1991
Mary Ellen Mortensen
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Military demonstrations as digital spectacles: How virtual presentations of AI decision-support systems shape perceptions of war and security

European Journal of International Security
The growing reliance of militaries on artificial intelligence (AI) and machine learning (ML) technologies means that private software companies are assuming an increasingly central role in the conception and development of the tools of contemporary ...
Robin Vanderborght, Anna Nadibaidze
doaj   +1 more source

Interview with Arthur Bruce Boenau, June 9, 2005

, 2005
Arthur Bruce Boenau was interviewed on June 9, 2005 by Michael Birkner about his life and time as a professor of Political Science at Gettysburg College.
Birkner, Michael J., Boenau, Arthur Bruce   +1 more
core  

Seeing Me in the Story: Representation of Multiracial Characters in Multimedia [PDF]

, 2019
In 2015, I discovered Saga, a graphic novel series that chronicles a science fiction story of war, family, and forbidden love. This series resonated with me because it is the first piece of pop culture that I invested in with a leading character whose ...
Vincent, Harvey M.
core   +1 more source

Science and war [PDF]

Nature, 2014
openaire   +2 more sources