Results 171 to 180 of about 17,038,828 (311)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

PubMed: an untapped source for open educational resource images. [PDF]

J Med Libr Assoc
Svoboda E, Connolly T.
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Références bibliographiques

Revue Internationale d’Éducation de Sèvres, 2009
Bernadette Plumelle
doaj   +1 more source

Correction: Automated self-service cohort selection for large-scale population sciences and observational research: The California Teachers Study researcher platform. [PDF]

PLoS One
PLOS One Staff.
europepmc   +1 more source

"Science for Society" and "Science for Science"

TRENDS IN THE SCIENCES, 2009
Ichiro KANAZAWA, Shinichiro OHGAKI, Kotaro SUZUMURA, Hideaki KARAKI, Mariko SAKURAI   +4 more
openaire   +2 more sources

Amplifications, Winter 2012, Vol. 5, No. 1 [PDF]

, 2012
Program in Audiology and Communication Sciences,
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Interprofessional recognition of audiology scope of practice in hearing and balance care: Evidence from the University of Sharjah. [PDF]

PLoS One
Ayas M, Ravi R, Gunjawate DR.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source