Results 41 to 50 of about 4,109,881 (267)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Acknowledgement to reviewers [PDF]
Journal of Interdisciplinary Sciences, 2022 The Journal of Interdisciplinary Sciences (JIS) wishes to thank all the reviewers for their intellectual contributions by timely reviewing manuscripts, and supporting the journal’s vision of “Enriching Beautiful Minds towards Intelligent Minds”.
Editor-in-Chief
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Jurnal Inovasi dan Teknologi Pembelajaran, 2020 Abstrak: Pada penelitian ini peneliti menggabungkan Scientific dan Cooperative Learning kemudian mengolaborasikannya dengan aplikasi pembelajaran Quizizz dalam meningkatkan hasil belajar siswa.
Samsul Adianto
doaj +1 more source
Defects, Scientific Computation and the Scientific Method [PDF]
, 2012 Computation has rapidly grown in the last 50 years so that in many scientific areas it is the dominant partner in the practice of science. Unfortunately, unlike the experimental sciences, it does not adhere well to the principles of the scientific method as espoused by for example, the philosopher Karl Popper.
openaire +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
SAHİB BİN ABBAD’S LİFE, PERİOD, ENVİRONMENT
Әл-Фараби Атындағы Қазақ Ұлттық Университеті хабаршы шығыстану сериясы, 2016 This article indicates that Sahib ibn Abbad who was prominent social, political, literary figure of l0th century lived and worked in Buveyhs Palace and was one of viziers of state.
Х Джафарли
doaj
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source