Results 91 to 100 of about 6,354,899 (321)

Regional Fisheries Advisory Committee 27th April, 1981

open access: yes, 1981
This is the report from the Regional Fisheries Advisory Committee meeting, which was held on the 27th April 1981.The report contains sections on the proceedings of the Local Fisheries Advisory Committee and recommendations for these committees ...

core  

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

open access: yesAdvanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun   +15 more
wiley   +1 more source

Regional Fisheries Advisory Committee 12th November, 1979.

open access: yes, 1979
This is the report from the Regional Fisheries Advisory Committee meeting, which was held on the 12th November 1979.The report contains the minutes of the previous meetings of the Local Fisheries Advisory Committees, information on fishing licence duties,

core  

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

open access: yesAdvanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li   +9 more
wiley   +1 more source

Regional Fisheries Advisory Committee 4th February, 1980.

open access: yes, 1980
This is the report from the Regional Fisheries Advisory Committee meeting, which was held on the 4th February 1980.The report contains the minutes of the Local Fisheries Advisory Committees, net and fixed engine licence duties, net limitation order for ...

core  

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee   +3 more
wiley   +1 more source

Illustrated capsules from the Advanced Course in Platelet Research

open access: yesResearch and Practice in Thrombosis and Haemostasis
This series of illustrated capsules summarizes the presentations made by the speakers at the first International Advanced Course in Platelet Research held in Murcia (Spain) from 27 to 28 September, 2024.
Christian Andrea Di Buduo   +41 more
doaj   +1 more source

Regional Fisheries Advisory Committee 12th July, 1979.

open access: yes, 1979
This is the report from the Regional Fisheries Advisory Committee meeting, which was held on the 12th July 1979.The report contains the minutes of the last meetings of the Local Fisheries Advisory Committees, the income from sale of rod and line licences,

core  

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

open access: yesAdvanced Science, EarlyView.
The schematic diagram depicts a compartmentalized anti‐ferroptotic defense mechanism mediated by GSTA4. GSTA4 is upregulated and localizes to the cytoplasm in ENZR cells, where it detoxifies 4‐HNE via a non‐canonical GSH‐dependent pathway. Under oxidative stress, GSTA4 translocates to mitochondria, interacts with PGAM5, and blocks Drp1 Ser637 ...
Yong Luo   +17 more
wiley   +1 more source

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

open access: yesAdvanced Science, EarlyView.
Cyclin‐dependent kinase (CDK) 1 activity is a dynamic marker of treatment response in estrogen receptor positive breast cancer. Patient cohorts reveal CDK1 activity increases during progression to invasive disease, where high expression correlates with poor survival. Using a novel Cdk1 biosensor mouse alongside in vitro models, we demonstrate that CDK1
Sarah Alexandrou   +17 more
wiley   +1 more source

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