Results 111 to 120 of about 977,510 (303)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Managing Sustainable Professional Development for Madrasah Teachers: Enhancing Scientific Publications

Al-Tanzim: Jurnal Manajemen Pendidikan Islam
Scientific publication activities are generally not the primary assessment of teacher performance in madrasahs, but scientific publications can impact teacher professionalism and the madrasah's reputation.
Mardia Mardia, Rahmawati Rahmawati, Suhailah Abdul Muin, Nurleli Ramli   +3 more
doaj   +1 more source

A survey of the European Open Science Cloud services for expanding the capacity and capabilities of multidisciplinary scientific applications [PDF]

, 2022
Amanda Calatrava, Hernán Asorey, J. Astaloš, Alberto Azevedo, Francesco Benincasa, Ignácio Blanquer, Martin Bobák, Francisco Brasileiro, Laia Codó, Laura del Caño, Borja Esteban, Meritxell Ferret, J. Handl, Tobias Kerzenmacher, В. Козлов, Aleš Křenek, Ricardo Martins, Manuel Pavesio, A. J. Rubio Montero, Juan Sánchez-Ferrero   +19 more
openalex   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Development of an index system for the scientific literacy of medical staff: a modified Delphi study in China

BMC Medical Education
Background Scientific research activity in hospitals is important for promoting the development of clinical medicine, and the scientific literacy of medical staff plays an important role in improving the quality and competitiveness of hospital research ...
Shuyu Liang, Ziyan Zhai, Xingmiao Feng, Xiaozhi Sun, Jingxuan Jiao, Yuan Gao, Kai Meng   +6 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The relationship among biodiversity, governance, wealth, and scientific capacity at a country level: Disaggregation and prioritization. [PDF]

Ambio, 2015
Lira-Noriega A, Soberón J.
europepmc   +1 more source

Scientific Data Base for Gear Carrying Capacities Tests

Jixie chuandong, 1998
The paper deals mainly with how to set up a scientific data base for gear carrying capacities tests. The contents, functions and design methods of the scientific data base are discused.
openaire   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source