Results 101 to 110 of about 9,101,925 (291)

Strengthening research management and support services in sub-Saharan African universities and research institutions - example interview guide

open access: yes
An ‘exemplar’ of the interview guides used across the eight projects from which data were drawn to inform the associated research ...
Centre for Capacity Research
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Division of Global Public Health Capacity Development 2007 annual report [PDF]

open access: yes
The Division of Global Public Health Capacity Development (DGPHCD) 2007 Annual Report is the third annual report. Since our last report, several organizational changes have occurred resulting in a name change and the addition of a program to our division.

core  

Playing With Reality: Emergency Capacity Building Project simulations case study

open access: yes, 2012
This Emergency Capacity Building (ECB) Project simulation case study focuses on the lessons learnt from implementing the ECB Project multi-agency simulations at the national level between April 2010 and March 2012, using the ECB Simulations ...
Lumsdon, Sarah, Hockaday, David
core   +1 more source

AN OVERVIEW OF THE EUROPEAN UNION RESILIENCE CAPACITY: SCIENTIFIC LIMITS AND METHODOLOGICAL ASPECTS RELATED TO ITS MEASUREMENT [PDF]

open access: yesAnnals of the University of Oradea: Economic Science, 2018
Over the last decade, the measures implemented to ensure development at European Union (EU) level were taken from the need to provide a stronger resilience capacity in order to respond adequately to various internal or external shocks that may occur and ...
Ramona Țigănașu
doaj  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Extended Data - How research consortia can contribute to improvements in PhD students’ research environment and progress in sub-Saharan African countries

open access: yes
Online questionnaire to PhD candidates, Interview guide PhD students, Participant information sheet, Consent ...
Centre for Capacity Research
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Annex 1 - Master List of WHO-AFR Countries with Indicators

open access: yes
Master List of WHO-AFR Countries with ...
Centre for Capacity Research
core   +1 more source

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