Results 111 to 120 of about 9,101,925 (291)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Annex 2 - Master List of HEIs

Master List of ...
Centre for Capacity Research
core   +1 more source

Early Grade Literacy in Latin America and the Caribbean: Jamaica Stakeholder Mapping and Analysis

, 2019
The LAC Reads Capacity Program (LRCP) aims to increase the impact, scale, and sustainability of early grade literacy (EGL) activities in priority countries in Latin America and the Caribbean (Jamaica, Haiti, Dominican Republic, Guatemala, Honduras ...
USAID/LAC Reads Capacity Program
core   +1 more source

Losing half our scientific capacity [PDF]

Nature Structural & Molecular Biology, 2007
openaire   +2 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Africa Capacity Report 2014: Capacity Imperatives for Regional Integration in Africa

, 2014
The Africa Capacity Report (ACR) and its supporting indicators offer inputs for decisions on what to finance to develop capacity. Most countries are doing well on their policy environments and having processes in place to implement policies.
African Capacity Building Foundation (19289548)
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Building research capacity in the global south: insights from a scientific writing workshop

BMC Medical Education
Background Health researchers in the Global South face many barriers to scientific publication, including language limitations, lack of access to mentorship, and minimal training opportunities.
Pierrette Ngutete Mukundwa, Barnabas Tobi Alayande, Divine Iradukunda, Betel Fenta, Georges Bucyibaruta, Oluwaseun Ojomo, Ireri Mbogo, Emmanuel Ngwakongnwi, Robert Riviello, Abebe Bekele, Henry E. Rice   +10 more
doaj   +1 more source

Scientific cooperation among Europe's One Health agencies

One Health
Over the years, the five EU agencies (ECDC, ECHA, EEA, EFSA, and EMA) dealing with One Health matters, have established scientific cooperation on a range of cross-cutting topics, including zoonoses, emerging risks, and antimicrobial resistance. Effective
Stefania Tampach, Ana Vidal, Ian Marnane, Wim De Coen, Ole Heuer, Carlos G. das Neves, Kerstin Gross-Helmert, Gorgias Garofalakis, Stef Bronzwaer   +8 more
doaj   +1 more source