Results 81 to 90 of about 9,101,925 (291)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Impact of Digital Government on Regional Scientific and Technological Innovation Capacity

Systems
Background and Purpose: Contemporary digital government initiatives in China face a well-documented real-world paradox: massive fiscal outlays on digital governance coexist with marked disequilibrium in regional innovation returns.
Zhengang Zhang, Defei Wang
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Collaboration in Iranian Scientific Publications [PDF]

, 2002
This study looks at international collaboration in Iranian scientific publications through the ISI Science Citation Index® (SCI) for the years 1995-1999, inclusive.
WILSON, CONCEPCIÓN S., Osareh, Farideh
core   +1 more source

Building research capacity in sub-Saharan Africa: findings from a pilot scientific writing workshop in Cameroon

BMC Research Notes
Objective Sub-Saharan Africa produces less than 4% of global scientific output, despite significant health and development challenges. This study evaluated the effectiveness of a pilot scientific writing workshop in Cameroon aimed at building writing ...
Solange Dabou, Valery Ngo Ngo, Ghyslaine Bruna Djeunang Dongho, Evrard Melvin Kepgang Nanseu, Regina Yuka Sinsai, Constantine T. Asahngwa, Odette Dzemo Kibu, Jessy Goupeyou-Youmsi, Fabrice Zobel Lekeumo Cheuyem, Anna Conner, Ronald M. Gobina, Denis A. Foretia   +11 more
doaj   +1 more source

From scientific literacy to civic capacity: school science education as civic infrastructure

Frontiers in Education
School science education has long been expected to prepare scientifically informed citizens, yet classroom practice and assessment often remain centered on conceptual understanding rather than on students’ capacity to use scientific knowledge in public ...
Aleixandre Brian Duche-Pérez, Milena Ketty Jaime-Zavala, Doris Cornejo Paredes   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

First detection and genomic analysis of mcr-1-positive Salmonella Infantis isolated from a broiler production system in the United Arab Emirates

Frontiers in Veterinary Science
This study reports the first detection of mcr-1.1-mediated colistin resistance in Salmonella enterica serovar Infantis from a commercial broiler farm in the United Arab Emirates (UAE). Two S.
Ihab Habib, Mohamed-Yousif Ibrahim Mohamed, Glindya Bhagya Lakshmi, Hassan Mohamed Al Marzooqi, Hanan Sobhy Afifi, Mohamed Gamal Shehata, Mohamed Gamal Shehata, Mohammed Elbediwi, Mohammed Elbediwi   +8 more
doaj   +1 more source