Results 151 to 160 of about 92,781 (302)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Scientific discourse in the era of open science: a response to Hall et al. regarding the Carbohydrate-Insulin Model. [PDF]

Int J Obes (Lond), 2019
Ludwig DS, Lakin PR, Wong WW, Ebbeling CB.   +3 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Reply to Musculus et al.: A case of offside in scientific discourse? [PDF]

Proc Natl Acad Sci U S A
Bonetti L, Vestberg T, Jafari R, Seghezzi D, Ingvar M, Kringelbach ML, Filgueiras A, Petrovic P.   +7 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Enhancing scientific discourse on penile girth augmentation: A critical appraisal of Chen et al.'s review. [PDF]

Curr Urol
Wang X.
europepmc   +1 more source

Ebola policies that hinder epidemic response by limiting scientific discourse. [PDF]

Am J Trop Med Hyg, 2015
Asgary R, Pavlin JA, Ripp JA, Reithinger R, Polyak CS.   +4 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Collocations in Modern English Scientific Discourse

, 2012
Pētījums ir koncentrēts uz valodas konteksta lietošanu dažādās zinātniskajās nozarēs. Mūsdienu Angļu valodas zinātniskais diskurss ir tikts pētīts, lai analizētu un pētītu akadēmisko vārdu veidošanos kopā ar citiem vārdiem mūsdienu zinātniskajā valodā ...
Pope, Raivis
core  

Using AI to enhance scientific discourse by transforming journals into learning communities. [PDF]

Arch Physiother
Rowe M.
europepmc   +1 more source