Results 141 to 150 of about 92,781 (302)
The alphabet of happenstance. On M. L. Gasparov’s Notes and excerpts. Pt. 1.
This article examines the new genre created by L. M. Gasparov — the ‘interdiscursive novel’. The author analyses characteristics of the genre, in particular, its termhood, research features, flexible interaction with methodology, and journalistic style ...
Isaev S.
doaj
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Learned discourses: Timely scientific opinions [PDF]
openaire +4 more sources
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Broadening shared knowledge within the specialized community in the 17th century
The aim of this paper is to illustrate the different methods that the specialized discourse community of the 17th century used to spread the news about the many activities then taking place and the discoveries being made by its members.
Maurizio Gotti
doaj
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Scientific Discourse in the Digital Era: A Statement
[Session abstract] The panel will discuss the character of scientific discourse in the digital era by considering these questions. • How has the character of scientific discourse developed in the digital era?
Pfeiffenberger, Hans
core
Preprint servers facilitate scientific discourse. [PDF]
Verma IM.
europepmc +1 more source

