Results 121 to 130 of about 92,781 (302)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
About the scientific discourse and its mediatization
, 2016 O artigo trata do discurso de divulgação científica, partindo do questionamento sobre se seria uma tradução, uma reformulação ou uma transformação do discurso científico.
Charaudeau, Patrick
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On Because Causality in Scientific Discourse
, 1991 Because is used for intentional transmission of causal information in discourse. In scientific writing, it is widely used connecting propositions which exhibit relations of ‘logical inference’ between them.
Sidiropoulou, Maria
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Scientific research is increasingly conducted digitally and online, and consequently we are seeing the emergence of new digital objects shared as part of the conduct and discourse of science.
De Roure, David +3 more
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Thank you for your critical comments and helpful suggestions
Ibérica, 2001 Peer reviews of research papers submitted to journals are an "occluded" genre (Swales, 1996) - referees are usually anonymous and the confidential reports themselves are not part of the official record of research publication.
Hugh Gosden
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
VOICE PROBLEMS IN TRANSLATIONS OF ROMANIAN AND ENGLISH ECONOMIC TEXTS [PDF]
The difficulties brought about by the passive constructions have been an issue to debate for many linguists and scientist. Translations become ever more important in an increasingly global marketplace, and they are sometimes taken too lightly, when in ...
Sim Monica Ariana
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Вестник Самарского университета: История, педагогика, филологияThe article deals with the geographical component of the chronotope of the English scientific discourse. The authors identify the forms of geographical representation of the chronotope of scientific discourse, determine the degree of identifiability of ...
S. A. Tserkovnov, K. B. Svoikin
doaj +1 more source