Results 101 to 110 of about 6,561,659 (253)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Early modern English news discourse: newspapers, pamphlets and scientific news discourse
, 2009 In Early Modern Britain, new publication channels were developed and new textual genres established themselves. News discourse became increasingly more important and reached wider audiences, with pamphlets as the first real mass media.
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Scientific Discourse and the Rhetoric of Globalization The Impact of Culture and Language
The rhetorical practices involved with the dissemination of scientific discourse are shifting. Addressing these changes, this book places the discourse of science in an increasingly multilingual and multicultural academic area.
Pérez-Llantada, Carmen. +1 more
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Role and position of scientific voices: reported speech in the media
, 2003 The purpose of this study is twofold: one, to determine the presence and function of scientific knowledge when it is required by such cases as "mad cows" disease, when the crisis breaks in the press; and two, to explore the role of scientific ...
Calsamiglia, Helena +1 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Scientific Discourse in Sociohistorical Context represents the intersection of knowledge and method, examined from the perspective of three distinct disciplines: linguistics, rhetoric-composition, and history.
Atkinson, Dwight.
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Narrative in the scientific discourse [PDF]
, 2016 The article is dedicated to the scientific discourse in the aspect of the narrative approach. Our objective was to investigate and analyze the specific traits of the research narrative in light of the act of persuasion. We have also compared the research
Шелковнікова, З.
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Towards Written Scientific-Technical Discourse Analysis:Statistical and Transformational Methods
The paper explores the organization of English scientific-technical discourse from the perspective of cohesion, texture and coherence. Key nouns are singled out from the discourse on the basis of a statistical criterion.
Liokumoviča, Irina
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