Results 81 to 90 of about 92,781 (302)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

SCIENTIFIC DISCOURSE IN ARTISTIC LITERATURE

open access: yes, 2020
The article distinguishes between the language of real life (a vital one) and the language of imaginary literature (an imaginary one). The aim of the article is to describe how a scientific discourse is presented in fictional works.
Asratyan, Zoya   +3 more
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The English Economic Term ‘Human Capital’ and Its Semantic Field in Scientific Discourse

open access: yesRUDN Journal of Language Studies, Semiotics and Semantics, 2019
Recently, human capital (HC) has acquired special relevance in response to digital economy development. A semantic study of HC is significant for its linguistic description and practical purposes of teaching business English to students, specializing in ...
Yulia A Filyasova
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Development of medical discourse

open access: yes, 2013
This chapter sketches an exemplary picture of the emergence and development of medical written discourse. Medical articles published in scientific journals during three centuries - the eighteenth, nineteenth and twentieth centuries - are analysed and ...
Gunnarsson, Britt-Louise,
core  

Beyond high hopes: A scoping review of the 2019-2021 scientific discourse on machine learning in medical imaging. [PDF]

open access: yesPLOS Digit Health, 2023
Nittas V   +8 more
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

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