Results 91 to 100 of about 92,781 (302)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Early modern English news discourse: newspapers, pamphlets and scientific news discourse
, 2009 In Early Modern Britain, new publication channels were developed and new textual genres established themselves. News discourse became increasingly more important and reached wider audiences, with pamphlets as the first real mass media.
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A prostitute’s progress: Male prostitution in scientific discourse
, 2003 This paper examines discourses of male prostitution through an analysis of scientific texts. A contrast is drawn between nineteenth-century understandings of male prostitution and twentieth-century accounts of male prostitution.
Scott, John, John Scott
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Choosing identities: the politics and practices of classroom discourse on reproductive and genetic technologies [PDF]
, 2007 In this thesis, I draw on contemporary social theory, media communication studies and discourse analysis to explore how micro-political discussions around identity and new reproductive and genetic technologies (NRGTs) in classroom discussions may be ...
Murphy, Padraig
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La lecture académique dans la perspective d’un écrit de transition
Studia Romanica PosnaniensiaAcademic reading can have different epistemic objectives and be situated at different levels, such as the development of disciplinary knowledge, the observation and development of scientific reasoning, as well as the awareness and refinement of reading ...
Bernadeta Wojciechowska +1 more
doaj +1 more source
Popular and Scientific Discourse on Autism: Representational Cross-Cultural Analysis of Epistemic Communities to Inform Policy and Practice. [PDF]
J Med Internet Res, 2022 Gauld C +3 more
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source